Results 181 to 190 of about 220,813 (310)

Molecular mechanism for direct actin force-sensing by α-catenin

, 2020
Lin Mei, Santiago Espinosa de los Reyes, Matthew J. Reynolds, Rachel Leicher, Shixin Liu, Gregory M. Alushin   +5 more
openalex   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions. [PDF]

MedComm (2020)
Jin X, Wang J, Cao R, Jiang D.
europepmc   +1 more source

Beta-catenin

Beta-catenin (CTNNB1) plays a dual role in the cell, functioning both in cell adhesion and WNT signalling. In cell adhesion, CTNNB1 binds to cadherins in adherens junctions and anchors them to the cytoskeleton. This is crucial for reinforcing cell-cell junctions and maintaining structural integrity.
openaire   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Altered PTPN13-β-catenin interaction by pathogenic mutations and involvement of this axis in B-cell receptor signalling. [PDF]

Sci Rep
Cabrera-Riofrío DA, Li H, García-Calvo C, Sánchez-Bernal C, Sánchez-Yagüe J, Dror Y, Buey RM, Hernández-Hernández Á.   +7 more
europepmc   +1 more source

RETRACTED ARTICLE: Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway [PDF]

, 2019
Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong   +3 more
openalex   +1 more source

A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway

, 2022
Yangyang Tian, Jiarui Xia, Guo Yang, Chao Li, Yuanmeng Qi, Kai Dai, Chenchen Wu, Yonghua Guo, Wu Yao, Changfu Hao   +9 more
openalex   +1 more source

Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes

Advanced Science, EarlyView.
In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, Changjun Li, Lina Niu, Jianfei Yan, Kai Jiao   +13 more
wiley   +1 more source

STT3A-mediated FCN3 N-glycosylation promotes Treg cell activation to drive hepatocellular carcinoma progression via Wnt/β-catenin. [PDF]

Cell Oncol (Dordr)
Zhang H, Zhang P, Gong T, Zhang C, Wang Z, Zhao Y.   +5 more
europepmc   +1 more source