Results 351 to 360 of about 414,710 (373)

Switching of α-catenin from αE-catenin in the cortical ventricular zone to αN-catenin II in the intermediate zone

Developmental Brain Research, 2005
Although cadherins and catenins are known to play important roles during neural development, the types of alpha-catenin present in the developing telencephalon are still unknown. Here, we show that the ventricular zones (VZ) of the cortex and the ganglionic eminences express alphaE-catenin and alphaN-catenin, respectively, in a complementary manner. In
Kazunori Nakajima, Kazunori Nakajima, Itsuki Ajioka   +2 more
openaire   +3 more sources

A specific domain in α-catenin mediates binding to β-catenin or plakoglobin

Journal of Cell Science, 1997
ABSTRACT The E-cadherin-catenin adhesion complex has been the subject of many structural and functional studies because of its importance in development, normal tissue function and carcinogenesis. It is well established that the cytoplasmic domain of E-cadherin binds either β-catenin or plakoglobin, which both can assemble α-catenin into
M. Krohn, Otmar Huber, Rolf Kemler
openaire   +3 more sources

Characterization of the interactions of α-catenin with α-actinin and β-catenin/plakoglobin

Journal of Cell Science, 1997
ABSTRACT Cadherins are calcium-dependent, cell surface glycoproteins involved in cell-cell adhesion. To function in cell-cell adhesion, the transmembrane cadherin molecule must be associated with the cytoskeleton via cytoplasmic proteins known as catenins.
Fang Jin, Ann R. Redfield, Margaret J. Wheelock, Karen A. Knudsen, Keith R. Johnson, Jill E. Nieset   +5 more
openaire   +2 more sources

Upregulation of γ-catenin compensates for the loss of β-catenin in adult cardiomyocytes

American Journal of Physiology-Heart and Circulatory Physiology, 2007
Recent progresses in signal transduction have revealed that β-catenin signaling controls embryonic development, tumorigenesis, cell shape, and polarity. The role of this pathway in myocyte shape regulation during cardiac hypertrophy and failure is, however, not clearly defined.
Faqian Li, Kelly Graber, Lu Huber, Xuejun Wang, Xian Ping Yi, Xian Ping Yi, Jiaxiang Qu, Jibin Zhou, A. Martin Gerdes   +8 more
openaire   +3 more sources

Catenins, Wnt signaling and cancer

BioEssays, 2000
Recent studies indicate that plakoglobin may have a similar function to that of beta-catenin within the Wnt signaling pathway. beta-catenin is known to be an oncogene in many forms of human cancer, following acquisition of stabilizing mutations in amino terminal sequences.
Nick Barker, Hans Clevers
openaire   +3 more sources

Re-expression of E-cadherin, α-catenin and β-catenin, but not of γ-catenin, in metastatic tissue from breast cancer patients

The Journal of Pathology, 2000
Tumour cell invasion and metastasis are the processes which kill most cancer patients. Tumour cells with the greatest invasive and metastatic capacity may be those with the highest number of genetic aberrations. The present study has analysed the expression of several tumour-related proteins in both primary tumours and metastatic lesions from 34 breast
Ida R. K. Bukholm, J. M. Nesland, Anne Lise Børresen-Dale   +2 more
openaire   +2 more sources

Role of β-catenin and Active Beta Catenin in Osteosarcoma Progression

2016
Osteosarcoma (OS) is the most common primary bone malignancy with a high incidence in children and adolescents. Current treatment strategies (surgery and adjuvant chemotherapy) has improved the overall survival rate of patients with primary OS. However, the survival rate of patients with metastatic disease still remains poor.
openaire   +2 more sources

Cadherins and catenins in pathology

Current Diagnostic Pathology, 2002
Abstract Cell adhesion is a vital process, essential for the establishment and maintenance of tissue architecture and differentiation. Cadherins are a large family of cell adhesion molecules, which mediate cell–cell adhesion via calcium dependent, homotypic interactions.
Amsha Ramburan, Dhirendra Govender
openaire   +2 more sources

Evolution and diversity of cadherins and catenins

Experimental Cell Research, 2017
Cadherin genes encode a superfamily of conserved transmembrane proteins that share an adhesive ectodomain composed of tandem cadherin repeats. More than 100 human cadherin superfamily members have been identified, which can be classified into three families: major cadherins, protocadherins and cadherin-related proteins.
Yvan Saeys, Frans van Roy, Paco Hulpiau, Ismail Sahin Gul   +3 more
openaire   +3 more sources

Inhibition of RhoA by p120 catenin

Nature Cell Biology, 2000
RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the formation of adherens junctions. The catenin p120 has also been implicated in cadherin clustering through an unknown mechanism.
Yi Zheng, Panos Z. Anastasiadis, Albert B. Reynolds, Debbie J. Mariner, Sun Y. Moon, Molly A. Thoreson, Howard C. Crawford   +6 more
openaire   +3 more sources