Biosynthesis of Ephedrine Initiated by Pyridoxal Phosphate-Dependent Formation of Cathinone. [PDF]
ChembiochemAn alternative pathway to ephedra alkaloids via (S)–cathinone is investigated in plants. This pathway circumvents the formation of 1‐phenylpropane‐1,2‐dione as an intermediate, which has been part of the predominantly postulated biosynthetic pathway for the last decades. This alternative pathway involves an enzymatic pyridoxal phosphate (PLP)‐dependent
Witte K +4 more
europepmc +2 more sources
Self-Care Practice in the Management of Hypertension Among Adults in Africa: Findings From a Scoping Review. [PDF]
Health Sci RepABSTRACT Background and Aims Effective self‐care for hypertension spans medication adherence and lifestyle practices (dietary salt reduction, physical activity, weight control, smoking/alcohol moderation). This scoping review summarizes self‐care strategies employed by adults with hypertension in Africa and identifies factors influencing their self ...
Adeosun A, Khan HTA, Lawal M.
europepmc +2 more sources
Post-stroke depression prevalence and associated factors at Hawassa University Hospital, Ethiopia: A prospective cross-sectional study. [PDF]
PCN RepAbstract Background Post‐stroke depression (PSD) is the most common neuropsychiatric complication following stroke. Although its prevalence varies across studies and meta‐analyses, it is estimated to affect over 25% of stroke survivors. Despite its significant negative impact on recovery and quality of life, PSD is frequently underdiagnosed ...
Seid A, Kuma A, Belete Y, Anegagregn A.
europepmc +2 more sources
The experiences of people who quit khat and the health care professionals who support them [PDF]
Addiction and Health, 2019 Background: This study aimed to explore the barriers and enablers to quitting khat from the perspective ofusers and the barriers and enablers to supporting users to quit from the perspective of healthcareprofessionals (HCPs).Methods: The present ...
Suhana Begum +2 more
doaj +1 more source
Mice, double deficient in lysosomal serine carboxypeptidases Scpep1 and Cathepsin A develop the hyperproliferative vesicular corneal dystrophy and hypertrophic skin thickenings. [PDF]
PLoS ONE, 2017 Vasoactive and mitogenic peptide, endothelin-1 (ET-1) plays an important role in physiology of the ocular tissues by regulating the growth of corneal epithelial cells and maintaining the hemodynamics of intraocular fluids.
Xuefang Pan +4 more
doaj +1 more source
Patients Reported Adverse Effects of Antidepressants Among Depressive Disorder and Associated Risk Factors: A Multicenter Cross-Sectional Study. [PDF]
Depress AnxietyBackground Over the last two decades, antidepressant usage has seen a notable rise. Following the initiation of antidepressant medication, numerous patients experience adverse drug reactions. The main objective of this research was to determine the adverse effects of antidepressants, and identify the associated factors for outpatients who had been ...
Chanie GS +10 more
europepmc +2 more sources
Glycemic effects of Catha edulis
Journal of Biological Research, 2022 More than 20 million people in the East African horn and the southern Arabian Peninsula chew khat (Catha edulis) on a daily basis. The glycemic effect of khat chewing, regardless of diabetes status, is still being debated.
Samih Abed Odhaib +2 more
doaj +1 more source
Evaluation of the cytotoxic and genotoxic potential of Khat (Catha edulis Forsk) extracts on human T lymphoblastoid cell line [PDF]
, 2004 This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1 ...
Al-Meshal +20 more
core +1 more source
Herbal highs: review on psychoactive effects and neuropharmacology [PDF]
, 2017 Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances.
Graziano, S +5 more
core +1 more source
KANDUNGAN FITOKIMIA DAN SENYAWA KATINON PADA DAUN KHAT MERAH (Catha edulis)
Sains Natural, 2018 Phytochemical Content and Katinon Coumpound in Red Khat (Catha edulis) Leaves      Khat Plant (Catha edulis) belongs to the Celastraceae family that originated in East Africa and the Arabian plateau.
Mimi Adhariani +2 more
doaj +1 more source