Results 51 to 60 of about 24,668 (220)

Cathelicidin attenuates hyperoxia-induced kidney injury in newborn rats

Renal Failure, 2019
Aim: Supplemental oxygen is often used to treat neonates with respiratory disorders. Human and animal studies have demonstrated that neonatal hyperoxia increases oxidative stress and induces damage and collagen deposition in kidney during the perinatal ...
Hsiu-Chu Chou, Chung-Ming Chen
doaj   +1 more source

DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

Медицинская иммунология, 2018
Granulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group
M. M. (Jr) Averbakh, L. V. Panova, M. F. Gubkina, N. I. Evseeva   +3 more
doaj   +1 more source

Cathelicidin promotes liver repair after acetaminophen-induced liver injury in mice

JHEP Reports, 2023
Background & Aims: Acetaminophen (APAP)-induced acute liver injury (AILI) is a leading cause of acute liver failure (ALF). N-acetylcysteine (NAC) is only effective within 24 h after APAP intoxication, raising an urgent need for alternative approaches
Tingting Zhai, Jingjing Zhang, Jie Zhang, Bilian Liu, Zhiguang Zhou, Feng Liu, Yan Wu   +6 more
doaj   +1 more source

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Albiol Matanic VC, Bayerl C, Berg M, Blount BW, Boguniewicz M, Bourinbaiar AS, Bradshaw J, Brogden NK, Brown JM, Carretero M, Christophers E, Ciornei CD, Conner K, Cork MJ, de Jongh GJ, Degitz K, Dempsey CE, Dubos RJ, Eiseman AS, Epand RF, Erdag G, Escher N, Falagas ME, Ge Y, Giacometti A, Glaser R, Gläser R, Gregory SM, Grossgebauer K, Guarna M, Guiliani A, Guttman-Yassky E, Hancock RE, Harder J, Harder J, Harder J, Hartmann D, Howell MD, Huttner KM, Imura Y, Jacob L, Jacobsen F, Jung K, Khandelia H, Koch-Weser J, Koczulla R, Korting HC, Kotlan B, Kretschmar M, Kretschmar M, Kretschmar M, Kreuter A, Kruse T, Lai Y, Lai YP, Lande R, Li Q, Lind HE, Liu AY, Madsen P, Mallow EB, Marincola FM, Maroti G, Melo MN, Mogi T, Muramatsu I, Nagy I, Nijnik A, Nomura I, Nussenblatt RB, Ong PY, Oono T, Pivarcsi A, Plebani M, Reddy KVR, Reddy KVR, Rieg S, Risso A, Ruckdeschel G, Rudolph B, Sader HS, Schauber J, Schauber J, Schittek B, Schittek B, Schneider JJ, Schröder JM, Schön MP, Seoh SA, Shai Y, Sigurdadottir T, Simmaco M, Steinstraesser L, Steinstraesser L, Steinstraesser L, Storm DR, Svinarich DM, Tang YQ, Voigt HU, Wang G, Wang Z, Willenberg W, Yamasaki K, Yamasaki K, Zairi A, Zanger P, Zasloff M   +106 more
core   +1 more source

Human Cathelicidin Production by the Cervix

PLoS ONE, 2014
hCAP18/LL-37 is the sole human cathelicidin; a family of host defence peptides with key roles in innate host defence. hCAP18/LL-37 is expressed primarily by neutrophils and epithelial cells, but its production and function in the lower genital tract is largely uncharacterised.
Frew, Lorraine, Makieva, Sofia, McKinlay, Andrew T M, McHugh, Brian J, Doust, Ann, Norman, Jane E, Davidson, Donald J, Stock, Sarah J   +7 more
openaire   +6 more sources

Snake Venom Cathelicidins as Natural Antimicrobial Peptides [PDF]

Frontiers in Pharmacology, 2019
Bioactive small molecules isolated from animals, plants, fungi and bacteria, including natural antimicrobial peptides, have shown great therapeutic potential worldwide. Among these peptides, snake venom cathelicidins are being widely exploited, because the variation in the composition of the venom reflects a range of biological activities that may be ...
Elizângela de Barros, Elizângela de Barros, Regina M. Gonçalves, Regina M. Gonçalves, Marlon H. Cardoso, Marlon H. Cardoso, Nuno C. Santos, Nuno C. Santos, Nuno C. Santos, Octávio L. Franco, Octávio L. Franco, Octávio L. Franco, Elizabete S. Cândido, Elizabete S. Cândido, Elizabete S. Cândido   +14 more
openaire   +4 more sources

Cathelicidin impact on inflammatory cells.

Central-European journal of immunology, 2015
Cathelicidins, like other antimicrobial peptides, exhibit direct antimicrobial activities against a broad spectrum of microbes, including both Gram-positive and Gram-negative bacteria, enveloped viruses, and fungi. These host-derived peptides kill the invaded pathogens by perturbing their cell membranes and can neutralize biological activities of ...
Agier, Justyna, Efenberger, Magdalena, Brzezińska-Błaszczyk, Ewa   +2 more
openaire   +3 more sources

Hubungan Kadar Vitamin D dan Cathelicidin Plasma dengan Kejadian Infeksi Tuberkulosis pada Anak dengan Kontak BTA Positif

Sari Pediatri, 2016
Latar belakang. Vitamin D dan cathelicidin berperan penting dalam sistem imun alamiah terhadap kuman tuberkulosis. Vitamin D memediasi sintesis cathelicidin, melalui ekspresi vitamin D nuclear reseptor (VDR) sehingga cathelicidin dapat membunuh kuman ...
Lola Lusita, Finny Fitri Yani, Netti Suharti   +2 more
doaj   +1 more source

The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation.

PLoS Biology, 2022
Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear.
Katie J Smith, Danielle Minns, Brian J McHugh, Rebecca K Holloway, Richard O'Connor, Anna Williams, Lauren Melrose, Rhoanne McPherson, Veronique E Miron, Donald J Davidson, Emily Gwyer Findlay   +10 more
doaj   +1 more source

Systemic Responses of Multidrug-Resistant Pseudomonas aeruginosa and Acinetobacter baumannii Following Exposure to the Antimicrobial Peptide Cathelicidin-BF Imply Multiple Intracellular Targets

Frontiers in Cellular and Infection Microbiology, 2017
Cathelicidin-BF, derived from the banded krait (Bungarus fasciatus), is a typically cationic, amphiphilic and α-helical antimicrobial peptide (AMP) with 30 amino acids that exerts powerful effects on multidrug-resistant (MDR) clinical isolates, including
Cunbao Liu, Bin Shan, Jialong Qi, Yanbing Ma   +3 more
doaj   +1 more source