Results 71 to 80 of about 24,735 (220)

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]

, 2020
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K, Saric-Bosanac, Suzana, Shi, Vivian Y, Sivamani, Raja K   +3 more
core  

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine [PDF]

, 2012
Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important ...
Albiol Matanic VC, Bayerl C, Berg M, Blount BW, Boguniewicz M, Bourinbaiar AS, Bradshaw J, Brogden NK, Brown JM, Carretero M, Christophers E, Ciornei CD, Conner K, Cork MJ, de Jongh GJ, Degitz K, Dempsey CE, Dubos RJ, Eiseman AS, Epand RF, Erdag G, Escher N, Falagas ME, Ge Y, Giacometti A, Glaser R, Gläser R, Gregory SM, Grossgebauer K, Guarna M, Guiliani A, Guttman-Yassky E, Hancock RE, Harder J, Harder J, Harder J, Hartmann D, Howell MD, Huttner KM, Imura Y, Jacob L, Jacobsen F, Jung K, Khandelia H, Koch-Weser J, Koczulla R, Korting HC, Kotlan B, Kretschmar M, Kretschmar M, Kretschmar M, Kreuter A, Kruse T, Lai Y, Lai YP, Lande R, Li Q, Lind HE, Liu AY, Madsen P, Mallow EB, Marincola FM, Maroti G, Melo MN, Mogi T, Muramatsu I, Nagy I, Nijnik A, Nomura I, Nussenblatt RB, Ong PY, Oono T, Pivarcsi A, Plebani M, Reddy KVR, Reddy KVR, Rieg S, Risso A, Ruckdeschel G, Rudolph B, Sader HS, Schauber J, Schauber J, Schittek B, Schittek B, Schneider JJ, Schröder JM, Schön MP, Seoh SA, Shai Y, Sigurdadottir T, Simmaco M, Steinstraesser L, Steinstraesser L, Steinstraesser L, Storm DR, Svinarich DM, Tang YQ, Voigt HU, Wang G, Wang Z, Willenberg W, Yamasaki K, Yamasaki K, Zairi A, Zanger P, Zasloff M   +106 more
core   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Structural and functional analysis of the pro-domain of human cathelicidin, LL-37 [PDF]

, 2013
Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain
Beckley, Amy J., Ericksen, Bryan, Lan, Liqiong, Li, Xiangdong, Ling, Minhua, Lu, Wuyuan, Pazgier, Marzena, Pozharski, Edwin, Shi, Jishu N., Toth, Eric, Yuan, Weirong, Zhan, Changyou, Zou, Guozhang   +12 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Flow-Based Fmoc-SPPS Preparation and SAR Study of Cathelicidin-PY Reveals Selective Antimicrobial Activity

Molecules, 2023
Antimicrobial peptides (AMPs) hold promise as novel therapeutics in the fight against multi-drug-resistant pathogens. Cathelicidin-PY (NH2-RKCNFLCKLKEKLRTVITSHIDKVLRPQG-COOH) is a 29-residue disulfide-cyclised antimicrobial peptide secreted as an innate ...
Shama Dissanayake, Junming He, Sung H. Yang, Margaret A. Brimble, Paul W. R. Harris, Alan J. Cameron   +5 more
doaj   +1 more source

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Mechanical ventilation (MV) of patients can cause
Gudjonsson, Thorarinn, Gudmundsson, Gudmundur Hrafn, Karadottir, Harpa, Karason, Sigurbergur, Kulkarni, Nikhil Nitin   +4 more
core   +3 more sources

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Cathelicidin – A Novel Potential Marker of Pediatric Inflammatory Bowel Disease

Journal of Inflammation Research, 2021
Paulina Krawiec, Elżbieta Pac-Kożuchowska Department of Pediatrics and Gastroenterology, Medical University of Lublin, Lublin, PolandCorrespondence: Paulina KrawiecDepartment of Pediatrics and Gastroenterology, Medical University of Lublin, Racławickie 1,
Krawiec P, Pac-Kożuchowska E
doaj  

A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea

EMBO Molecular Medicine, 2021
Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here, several lines of evidence were provided to demonstrate that mTORC1 signaling is hyperactivated in the skin, especially in the epidermis, of both rosacea patients and a ...
Zhili Deng, Mengting Chen, Yingzi Liu, San Xu, Yuyan Ouyang, Wei Shi, Dan Jian, Ben Wang, Fangfen Liu, Jinmao Li, Qian Shi, Qinqin Peng, Ke Sha, Wenqin Xiao, Tangxiele Liu, Yiya Zhang, Hongbing Zhang, Qian Wang, Lunquan Sun, Hongfu Xie, Ji Li   +20 more
doaj   +1 more source