Results 91 to 100 of about 17,552 (216)

A Stacking Ensemble Machine Learning Model for Predicting Vitamin D Deficiency in Bangladeshi Infants

Vector: The Journal of Engineering, Volume 2027, Issue 1, January/December 2027.
This study uses machine learning to predict vitamin D levels in Bangladeshi infants aged 12–24 months, addressing deficiency despite abundant sunlight. A stacking ensemble model combining Gaussian regressor, extra trees and XGBoost achieved the highest accuracy (R2$R^2$: 0.933, RMSE: 3.312).
Sadia Nasrin Tuly, Shatabdi Majumder, Koushik Roy, Md. Easin, Saha Reno, Golam Moktader Nayeem, Ahosan Habib, Atoshi Chowdhury   +7 more
wiley   +1 more source

Investigation of the effects of antimicrobial peptides and vitamin D in breast cancer

Medicine Science
Breast cancer is the most common cancer in women. In recent years, there have been studies on the effectiveness of cathelicidins, one of the antimicrobial peptides, especially in breast cancer.
Nurcan Umur, Funda Kosova, Bahadir Cetin, Ozgu Kemal Beksac   +3 more
doaj   +1 more source

Stimuli‐Responsive Lipid‐Based Nanocarriers for Antimicrobial Therapy

Advanced Therapeutics, Volume 9, Issue 11, November 2026.
This manuscript demonstrated, through a scoping review of the literature, that modifying lipid nanocarriers with organic and inorganic excipients is a promising alternative to increase in vitro drug release of antimicrobial compounds under the studied stimulus and significantly enhance in vitro and in vivo antimicrobial activity compared to isolated ...
Brenda Maria Silva Bezerra, Adrian Lima Roberto, Luiz Gustavo Girão Lima, Mariana Rillo Sato, Leila Aparecida Chiavacci, João Augusto Oshiro‐Junior   +5 more
wiley   +1 more source

Thermal tolerance of cathelicidin-RC1.

, 2014
Thermal tolerance of cathelicidin-RC1 was determined by measuring MICs after incubation at different temperatures. Cathelicidin-RC1 solution (2 mg/ml, dissolved in sterile deionized water) was incubated at different temperatures (4, 20, 37, 50, 70, and ...
Guiying Ling (543925), Zeping Xie (543927), Shumin Zhang (187205), Lin Wei (70005), Haining Yu (227578), Jiuxiang Gao (543926), Yipeng Wang (9800)   +6 more
core   +1 more source

Helicobacter pylori Infection Remodels Neutrophil‐Derived Extracellular Vesicles, Promoting Stress and Apoptosis in Infected Epithelial Cells

Journal of Extracellular Vesicles, Volume 15, Issue 11, November 2026.
We report that Helicobacter pylori reprograms neutrophils to release extracellular vesicles (HPN‐EVs) with distinct biophysical and molecular features. These neutrophil‐derived vesicles, enriched in neutrophil granule proteins, LL‐37 and pro‐apoptotic miRNAs, suppress epithelial PI3K/Akt signalling, increase ROS, and induce mitochondrial dysfunction ...
Anand Kumar Keshri, Suraj Singh Rawat, Durganand Thakur, Swati Sharma, Parul Mehra, Anubha Chaudhary, Ananaya Kapoor, Amit Prasad   +7 more
wiley   +1 more source

Cathelicidin modulates synthesis of Toll-like Receptors (TLRs) 4 and 9 in colonic epithelium [PDF]

, 2017
Cathelicidin are innate antimicrobial peptides with broad immunomodulatory functions; however, their role in regulating intestinal defenses is not well characterized.
Marin, Maia Solange, Shah, Chaitanya B., Holani, Ravi, Odeón, Anselmo Carlos, Cobo, Eduardo Ruben, Chaitanya B. Shah, Ravi Holani, Maia Marin, Eduardo R. Cobo, Anselmo Odeón   +9 more
core   +1 more source

Nasal cathelicidin is expressed in early life and is increased during mild, but not severe respiratory syncytial virus infection

Scientific Reports
Respiratory syncytial virus is the major cause of acute lower respiratory tract infections in young children, causing extensive mortality and morbidity globally, with limited therapeutic or preventative options.
Sofia Sintoris, Justyna M. Binkowska, Jonathan L. Gillan, Roy P. Zuurbier, Jonathan Twynam-Perkins, Maartje Kristensen, Lauren Melrose, Paula Lusaretta Parga, Alicia Ruiz Rodriguez, Mei Ling Chu, Sara R. van Boeckel, Joanne G. Wildenbeest, Dawn M. E. Bowdish, Andrew J. Currie, Ryan S. Thwaites, Jurgen Schwarze, Marlies A. van Houten, James P. Boardman, Steve Cunningham, Debby Bogaert, Donald J. Davidson   +20 more
doaj   +1 more source

Avian host defense cathelicidins: structure, expression, biological functions, and potential therapeutic applications

Poultry Science, 2020
Host defense peptides (HDP) are multifunctional effectors of the innate immune system, which has antimicrobial and pleiotropic immunomodulatory functions.
Yingjie Wang, Min Wang, Anshan Shan, Xingjun Feng   +3 more
doaj   +1 more source

Curcumin in the Treatment of Various Diseases: Mechanism of Action, Bioavailability, Therapeutic Effects, and Current Clinical Trials

MedComm, Volume 7, Issue 11, November 2026.
Curcumin, a naturally occurring polyphenol, exhibits significant anti‐inflammatory and antioxidant capabilities. This review elucidates the specific molecular mechanisms by which curcumin exerts therapeutic effects on various diseases, including neurological disorders, cardiovascular diseases, cancers, inflammatory disorders, and autoimmune diseases ...
Lin Wang, Qifei Pan, Wenjuan Long, Xinyao Li, Jianqin Mao, Sitong Zhou, Zihui Wang, Xuelian Zou, Yuqing She, Mingqin Shi, Yang Zhou, Jiarong Du, Zhongyang Hu, Xiaoman Lv, Yishu Chen, Dongdong Qin   +15 more
wiley   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source