Results 71 to 80 of about 24,668 (220)

The role of hypothalamus-pituitary-adrenal (HPA)-like axis in inflammatory pilosebaceous disorders [PDF]

, 2020
Skin is the largest peripheral endocrine organ and functions as a hormone target and endocrine gland. A cutaneous hypothalamus-pituitary-adrenal (HPA)-like axis enables the skin to respond to stress and regulates its steroidogenic activity.
Clark, Ashley K, Saric-Bosanac, Suzana, Shi, Vivian Y, Sivamani, Raja K   +3 more
core  

Structural and functional analysis of the pro-domain of human cathelicidin, LL-37 [PDF]

, 2013
Cathelicidins form a family of small host defense peptides distinct from another class of cationic antimicrobial peptides, the defensins. They are expressed as large precursor molecules with a highly conserved pro-domain known as the cathelin-like domain
Beckley, Amy J., Ericksen, Bryan, Lan, Liqiong, Li, Xiangdong, Ling, Minhua, Lu, Wuyuan, Pazgier, Marzena, Pozharski, Edwin, Shi, Jishu N., Toth, Eric, Yuan, Weirong, Zhan, Changyou, Zou, Guozhang   +12 more
core   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells [PDF]

, 2015
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Mechanical ventilation (MV) of patients can cause
Gudjonsson, Thorarinn, Gudmundsson, Gudmundur Hrafn, Karadottir, Harpa, Karason, Sigurbergur, Kulkarni, Nikhil Nitin   +4 more
core   +3 more sources

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis

The Journal of Dermatology, EarlyView.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and microbial dysbiosis. Recent studies have highlighted the multifaceted roles of antimicrobial peptides (AMPs) both as innate defenders against microbial invasion and as regulators of immune responses and skin barrier ...
Ge Peng, Alafate Abudouwanli, Quan Sun, Yi Tan, Wanchen Zhao, Mengyao Yang, Shan Wang, Hideoki Ogawa, Ko Okumura, François Niyonsaba   +9 more
wiley   +1 more source

Flow-Based Fmoc-SPPS Preparation and SAR Study of Cathelicidin-PY Reveals Selective Antimicrobial Activity

Molecules, 2023
Antimicrobial peptides (AMPs) hold promise as novel therapeutics in the fight against multi-drug-resistant pathogens. Cathelicidin-PY (NH2-RKCNFLCKLKEKLRTVITSHIDKVLRPQG-COOH) is a 29-residue disulfide-cyclised antimicrobial peptide secreted as an innate ...
Shama Dissanayake, Junming He, Sung H. Yang, Margaret A. Brimble, Paul W. R. Harris, Alan J. Cameron   +5 more
doaj   +1 more source

Endogenous cathelicidin production limits inflammation and protective immunity to Mycobacterium avium in mice [PDF]

, 2013
The production of antimicrobial peptides, such as the cathelicidins, plays a prominent role in the innate immune response against microbial pathogens. Cathelicidins are widely distributed amongst living organisms, and the antimicrobial peptides generated
Appelberg, R., Gallo, R. L., Gama, F. M., Rosa, G., Santos, J. C., Silva, João P., Silva-Gomes, S.   +6 more
core   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

The seasonality of tuberculosis, sunlight, vitamin D, and household crowding. [PDF]

, 2014
BACKGROUND: Unlike other respiratory infections, tuberculosis diagnoses increase in summer. We performed an ecological analysis of this paradoxical seasonality in a Peruvian shantytown over 4 years. METHODS: Tuberculosis symptom-onset and diagnosis dates
Adams, Akhtar, Ane-Anyangwe, Anibarro, Arnedo-Pena, Baker, C. A. Evans, C. Jongkaewwattana, Chew, Dowling, Drucker, E. S. Ramos, Ford, G. Sandhu, J. J. Lewis, J. S. Friedland, K. Zevallos, Kennel, Liu, Lonnroth, Luquero, M. A. Tovar, M. R. Baldwin, Martineau, Nagayama, Onifade, Parrinello, R. H. Gilman, R. Montoya, Rao, Rook, S. G. Schumacher, Schaaf, Stamp, T. Wingfield, ten Asbroek, Wilkinson, Yang, Yoshiyama   +38 more
core   +2 more sources