Results 121 to 130 of about 13,268,265 (360)
Methods for the Generation of Single‐Payload Antibody‐Drug Conjugates
ChemMedChem, EarlyView.Antibody‐drug conjugates (ADCs) have emerged as a powerful form of targeted therapeutic. However, despite the myriad methods to generate even‐integer drug‐to‐antibody ratio (DAR) ADCs, strategies to generate DAR 1 are seldom reported despite the property tuning advantages of low drug loading or in enabling access to antibody‐protein constructs.
Thomas Wharton, David R. Spring
wiley +1 more source
DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Our data suggest DNA damage contributes to age‐associated differences in SARS‐CoV‐2 infection and provide a novel target for anti‐viral intervention. Abstract Coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is known to disproportionately affect older individuals.
Rui Jin +14 more
wiley +1 more source
Natural Cohen-Macaulayfication of simplicial affine semigroup rings [PDF]
arXiv, 2010 Let $K$ be a field, $B$ a simplicial affine semigroup, and $C(B)$ the corresponding cone. We will present a decomposition of $K[B]$ into a direct sum of certain monomial ideals, which generalizes a construction by Hoa and St\"uckrad. We will use this decomposition to construct a semigroup $\tilde B$ with $B \subseteq \tilde B \subseteq C(B)$ such that $
arxiv
ChemMedChem, EarlyView.Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali +11 more
wiley +1 more source
Plasma proteomic signature of decline in gait speed and grip strength
Aging Cell, Volume 21, Issue 12, December 2022., 2022 Several plasma proteins were associated with physical function decline in adults from middle to older age, including GDF‐15, pleiotrophin, and TIMP‐1 for gait speed decline, and CA III, CDON, and SMOC1 for grip strength decline. These novel proteomic biomarkers may by explored as future mechanisms and targets for age‐related functional decline ...
Xiaojuan Liu +11 more
wiley +1 more source
CyTA - Journal of Food, 2019 In order to evaluate the relationship between of endogenous enzymes and physiochemical indicators during the processing of dry-salted Decapterus maruadsi produced by the traditional method.
Yan Yan Wu +6 more
doaj +1 more source
Sharp Inequalities between Harmonic, Seiffert, Quadratic and Contraharmonic Means [PDF]
arXiv, 2012 In this paper, we present the greatest values $\alpha$, $\lambda$ and $p$, and the least values $\beta$, $\mu$ and $q$ such that the double inequalities $\alpha D(a,b)+(1-\alpha)H(a,b)
arxiv
Clinical Pharmacology in Drug Development, EarlyView.Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou +7 more
wiley +1 more source
Journal of Inflammation Research, 2022 Lan Ma,1,2 Zhengpu Han,1,2 Haoyu Yin,1,2 Jiaqi Tian,1,2 Jing Zhang,3 Ning Li,3 Chunjie Ding,4 Lin Zhang2 1School of Public Health, Weifang Medical University, Weifang, 261053, People’s Republic of China; 2Clinical Medical Research Center for Women and ...
Ma L +7 more
doaj
Two cathepsins B are responsible for the yolk protein hydrolysis in Culex quinquefasciatus.
PLoS ONE, 2015 Despite the established role of Culex quinquefasciatus as a vector of various neurotropic viruses, such as the Rift Valley and West Nile viruses, as well as lymphatic filariasis, little is known regarding the organism's reproductive physiology.
Alexandre S Moura +4 more
doaj +1 more source