Results 121 to 130 of about 25,778,187 (334)

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

The anti-phytoalexin gene Bx-cathepsin W supports the survival of Bursaphelenchus xylophilus under Pinus massoniana phytoalexin stress

BMC Genomics, 2019
Background Pine trees challenged by Bursaphelenchus xylophilus invasion produce phytoalexins to combat this nematode. Nevertheless, the phytoalexins of Asian pine trees are ineffective against B. xylophilus. The anti-phytoalexin genes of B.
Feng Wang, Qiaoli Chen, Ruizhi Zhang, Danlei Li, Yaming Ling, Ruiqing Song   +5 more
doaj   +1 more source

Cathepsin-B induced controlled release from peptide-capped mesoporous silica nanoparticles.

Chemistry, 2014
New capped silica mesoporous nanoparticles for intracellular controlled cargo release within cathepsin B expressing cells are described. Nanometric mesoporous MCM-41 supports loaded with safranin O (S1-P) or doxorubicin (S2-P) containing a molecular gate
Cristina de la Torre, Laura Mondragón, C. Coll, F. Sancenón, M. D. Marcos, R. Martínez-Máñez, P. Amorós, E. Pérez-Payá, M. Orzáez   +8 more
semanticscholar   +1 more source

Cathepsin B activity regulation - Heparin-like glycosaminoglycans protect human cathepsin B from alkaline pH-induced inactivation

, 2001
It has been shown that lysosomal cysteine proteinases, specially cathepsin B, has been implicated in a variety of diseases involving tissue remodeling states, such as inflammation, parasite infection, and tumor metastasis, by degradation of extracellular
Juliano, Luiz [UNIFESP, Chagas, Jair Ribeiro [UNIFESP], Nantes, I. L., Faljoni-Alario, A., Carmona, E., Tersariol, Ivarne Luis dos Santos [UNIFESP], Rizzi, CCA, Almeida, P. C., Nader, Helena Bonciani [UNIFESP]   +8 more
core   +1 more source

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.

PLoS ONE
Down syndrome, resulting from trisomy of human chromosome 21, is a common form of chromosomal disorder that results in intellectual disability and altered risk of several medical conditions. Individuals with Down syndrome have a greatly increased risk of
Yixing Wu, Karen Cleverley, Frances K Wiseman   +2 more
doaj   +1 more source

RETRACTED: Mechanism of p27 upregulation induced by downregulation of cathepsin B and uPAR in glioma

Molecular Oncology, 2011
Cathepsin B and urokinase plasminogen activator receptor (uPAR) are overexpressed in gliomas. Deregulation of the G1 phase cell cycle machinery is a common feature of cancers. p27Kip1 (p27) is one of the major cyclin‐CDK regulators in the G1 phase.
Sreelatha Gopinath, Kiranmai Alapati, Rama Rao Malla, Christopher S. Gondi, Sanjeeva Mohanam, Dzung H. Dinh, Jasti S. Rao   +6 more
doaj   +1 more source

Enhanced levels of cathepsin B mRNA in murine tumors [PDF]

, 1989
Relative amounts of mRNA for cathepsin B were measured in normal murine liver and three murine tumors, an invasive liver tumor (hepatoma, Hepa cl 9) and two melanoma variants (B16-F1 and B16 amelanotic melanoma, B16a). Using a human cDNA to the cathepsin
Moin, Kamiar, Sloane, Bonnie F., Jurij Rozhin, Sanders, Virginia J., Timothy B. McKernan, Virginia J. Sanders, McKernan, Timothy B., Honn, Kenneth V., Kenneth V. Honn, Fong, Dunne, Bonnie F. Sloane, Kamiar Moin, Dunne Fong, Rozhin, Jurij   +13 more
core   +1 more source

Human tumor cathepsin B. comparison with normal liver cathepsin B

, 1992
Cathepsin B was purified from normal human liver and several human tumour tissues and partially characterized. Three forms of cathepsin B, with molecular masses of 25 kDa, 26 kDa (the two appearing as a doublet) and 30 kDa, were detected in SDS ...
Sameni, M., Moin, K., Hasnain, Sadiq, Sloane, B., Day, N., Hirama, Tomoko   +5 more
core  

Figure S1 from Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody–Drug Conjugates

, 2017
Supplementary Figure 1: Loss of cathepsin B in cells. Cathepsin B enzymatic assays for various gRNAs tested against cathepsin B in KPL-4 cells (A) and BT-474M1 (B). IP/WB for cathepsin B expression in KPL-4 cells (C) and BT-474M1 (D).
Benjamin Haley (1383399), Niña G. Caculitan (14929112), Jack Sadowsky (4952815), Tommy K. Cheung (8612133), Katherine R. Kozak (1958674), Andrew G. Polson (1593544), Robert W. Akita (14929115), Thomas H. Pillow (3996851), Donglu Zhang (2102533), Mark X. Sliwkowski (2948271), Byoung-Chul Lee (469367), Josefa dela Cruz Chuh (1958668), Qui Phung (469358), Yong Ma (381691), Yichin Liu (1503172)   +14 more
core   +1 more source

Click‐Spaltung quartärer Anilinium‐Tetrazine ermöglicht Kaskadenaufbau multifunktioneller biomolekularer Gerüste

Angewandte Chemie, EarlyView.
Die Click‐Chemie hat sich von dem Aufbau kovalenter Bindungen hin zum Spalten von Bindungen weiterentwickelt. Hier wird über einen Kaskaden‐Aufbau berichtet, der diese Verfahren kombiniert, um multifunktionale biomolekulare Gerüste in einer modularen Ein‐Topf‐Reaktion aufzubauen.
Markus Staudt, Christian B. M. Poulie, Andreas Löffler, Peter R. Meinig, Riley J. Deutsch‐Williams, Barbara Herrmann, Ralph Weissleder, Hannes Mikula, Jonathan C. T. Carlson, Matthias M. Herth   +9 more
wiley   +1 more source