Results 131 to 140 of about 12,525,351 (366)

Gene structure of mouse cathepsin B

FEBS Letters, 1990
The structure of a genomic DNA fragment encoding mouse cathepsin B was characterized. The genomic insert spans 15 kbp and contains 9 exons encoding the 339 amino acid residues of mouse preprocathepsin B. Intron break‐points are not found at the junctions of the pre‐peptide, pro‐peptide and mature enzyme. Like other cysteine proteinase genes, the region
Ferrara, Marc, Wojcik, F., Rhaissi, H., Mordier, Sylvie, Roux, M.P., Bechet, Daniel   +5 more
openaire   +3 more sources

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Reduction of Cystatin B results in increased cathepsin B activity in disomic but not Trisomy 21 human cellular and mouse models.

PLoS ONE
Down syndrome, resulting from trisomy of human chromosome 21, is a common form of chromosomal disorder that results in intellectual disability and altered risk of several medical conditions. Individuals with Down syndrome have a greatly increased risk of
Yixing Wu, Karen Cleverley, Frances K Wiseman   +2 more
doaj   +1 more source

Two cathepsins B are responsible for the yolk protein hydrolysis in Culex quinquefasciatus.

PLoS ONE, 2015
Despite the established role of Culex quinquefasciatus as a vector of various neurotropic viruses, such as the Rift Valley and West Nile viruses, as well as lymphatic filariasis, little is known regarding the organism's reproductive physiology.
Alexandre S Moura, André F Cardoso, André L Costa-da-Silva, Carlos E Winter, A Tania Bijovsky   +4 more
doaj   +1 more source

Correction to: Inhibition of cathepsin B by caspase-3 inhibitors blocks programmed cell death in Arabidopsis [PDF]

, 2018
Yuan Ge, Y-M. Cai, L. Bonneau, Vitalyi Rotari, Antoine Danon, Edward A. McKenzie, Hazel McLellan, Lukas Mach, Patrick Gallois   +8 more
openalex   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

65. Cathepsin B-Labile Polymers for Endosome/Lysosome-Specific Degradation and Nucleic Acid Release [PDF]

, 2011

openalex   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma [PDF]

, 2000
Akiharu Dohchin, Junichi Suzuki, Hideyuki Seki, Manabu Masutani, Hiroshi Shiroto, Yoshikazu Kawakami   +5 more
openalex   +1 more source

Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability

, 2022
Zhi Li, Hang Li, Fan Jiang, Zhaolin Wang, Wei Zhang   +4 more
openalex   +1 more source