Results 191 to 200 of about 13,268,265 (360)

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

open access: yesSmall Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim   +7 more
wiley   +1 more source

The Activation of Trypsinogen by Cathepsin B

open access: yesJournal of Biological Chemistry, 1959
Irving Shoichet   +2 more
openaire   +3 more sources

Cathepsin B efficiently activates the soluble and the tumor cell receptor-bound form of the proenzyme urokinase-type plasminogen activator (Pro-uPA).

open access: hybrid, 1991
Hiroshi Kobayashi   +8 more
openalex   +1 more source

Dissecting Microscopic Colitis Immunopathophysiology: Insights From Basic Research

open access: yesUnited European Gastroenterology Journal, EarlyView.
ABSTRACT Microscopic colitis is an inflammatory bowel disease (IBD) comprising two clinically undiscernible entities: collagenous colitis and lymphocytic colitis. Collagenous colitis associates with HLA genes and displays a Th1/Tc1–Th17/Tc17 profile with pericryptal myofibroblast activity, water malabsorption and secondary fluid loss due to altered ...
Andreas Münch   +1 more
wiley   +1 more source

Cathepsin B and L activities in isolated osteoclasts

open access: hybrid, 1991
Barry R. Rifkin   +5 more
openalex   +1 more source

Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success. [PDF]

open access: yesNat Commun
Bird LE   +8 more
europepmc   +1 more source

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