Results 281 to 290 of about 13,268,265 (360)

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, EarlyView.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source

Interleukin-6/soluble IL-6 receptor-induced secretion of cathepsin B and L from human gingival fibroblasts is regulated by caveolin-1 and ERK1/2 pathways. [PDF]

Front Dent Med
Goto A, Omori K, Yamaguchi-Tomikawa T, Kobayashi H, Shinoda-Ito Y, Hirai K, Ikeda A, Takashiba S.   +7 more
europepmc   +1 more source

Protein succinylome analysis identifies citrate synthase as a central regulator of osteoclast metabolic activity

The FEBS Journal, EarlyView.
RANKL treatment induces expression of the aconitate decarboxylase (ACOD1) in differentiating osteoclasts, which increases succinate levels. The initially high expression of ACOD1 decreases towards the end of differentiation when the levels of the desuccinylase SIRT5 increase. Succinylation of citrate synthase (CS) was detected exclusively in stimulated
Dayoung Yu, Yue Gao, Marcin Luzarowski, Elisabeth Seebach, Thomas Heitkamp, Michael Börsch, Thomas Ruppert, Katharina F. Kubatzky   +7 more
wiley   +1 more source

Enteropathogenic E. coli effector Map interacts with Rab13 and regulates the depletion of the tight junction proteins occludin and claudins via cathepsin B-mediated mechanisms. [PDF]

Biol Open
Mandal A, Walling P, Qureshi S, Kansal K, Aijaz S.   +4 more
europepmc   +1 more source

Epidermal proteomics demonstrates Elafin as a psoriasis‐specific biomarker and highlights increased anti‐inflammatory activity around psoriatic plaques

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Epidermal sampling of lesional, perilesional and non‐lesional skin from psoriasis and eczema patients as well as healthy skin was used to perform an in depth proteomic analysis. IL‐36γ known to be expressed in lesional psoriasis skin was outperformed by the protease inhibitor Elafin as a disease‐specific epidermal biomarker.
Anna Berekmeri, Tom Macleod, Isabel Hyde, Gregor Jan Ojak, Caroline Mann, Daniela Kramer, Martin Stacey, Miriam Wittmann   +7 more
wiley   +1 more source

Correction: The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. [PDF]

Mol Neurodegener
Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.   +34 more
europepmc   +1 more source

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons. [PDF]

Mol Neurodegener
Jones-Tabah J, He K, Karpilovsky N, Senkevich K, Deyab G, Pietrantonio I, Goiran T, Cousineau Y, Nikanorova D, Goldsmith T, Del Cid Pellitero E, Chen CX, Luo W, You Z, Abdian N, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Miliukhina I, Timofeeva A, Emelyanov A, Pchelina S, Greenbaum L, Hassin-Baer S, Alcalay RN, Milnerwood A, Durcan TM, Gan-Or Z, Fon EA.   +34 more
europepmc   +1 more source

Biomarkers in Peri‐Implant Crevicular Fluid of Healthy Implants and Those With Peri‐Implant Diseases: A Systematic Review and Meta‐Analysis

Journal of Oral Pathology &Medicine, EarlyView.
ABSTRACT Introduction Several biomarkers in peri‐implant crevicular fluid have been studied to diagnose peri‐implant diseases with inconclusive results. This systematic review and meta‐analysis aimed to comprehensively compare data on the levels of biological components in peri‐implant crevicular fluid collected from healthy and diseased implants to ...
Gerardo La Monaca, Nicola Pranno, Romeo Patini, Antonella Polimeni, Massimo Cordaro, Maria Paola Cristalli   +5 more
wiley   +1 more source

Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin-Drug Conjugates. [PDF]

Bioconjug Chem
Bernardim B, Conde J, Hakala T, Becher JB, Canzano M, Vasco AV, Knowles TPJ, Cameron J, Bernardes GJL.   +8 more
europepmc   +1 more source

Salivary Proteomics for Detecting Novel Biomarkers of Periodontitis: A Systematic Review

Journal of Periodontal Research, EarlyView.
Untargeted salivary proteomics identified promising biological molecules consistently over‐ or under‐expressed in periodontitis patients compared to periodontally healthy subjects, but further targeted approaches are required for their validation. ABSTRACT Aim Salivary content is regarded as a powerful diagnostic window for oral and systemic diseases ...
Matteo Corana, Giacomo Baima, Giovanni Iaderosa, Francesco Franco, Jianjian Zhang, Giovanni Nicolao Berta, Federica Romano, Mario Aimetti   +7 more
wiley   +1 more source