Results 261 to 270 of about 122,992 (302)

Cathepsin B in Human Leukocytes

cclm, 1998
Abstract We have applied a method using the fluorigenic substrate benzoloxycarbonyl-Arg-Arg-amido-4-methylcoumarin to measure cathepsin B, a thiol proteinase, in homogenates of human leukocytes. Data like pH optimum, stability, influence of thiol groups and effects of thiol proteinase inhibitors, lack of binding to Concanavalin A and ...
den Tandt, Wilfried, Scharpe, Simon
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Tumor Cell Membrane Cathepsin B

bchm, 1998
The lysosomal cysteine peptidase cathepsin B was found to be associated with plasma membrane/endosomal fractions of murine B16 amelanotic melanoma cells. Confocal microscopy with three dimensional image analysis indicated that cathepsin B was associated with the external basal cell surface, which would be consistent with its proposed role in ...
K, Moin, L, Cao, N A, Day, J E, Koblinski, B F, Sloane   +4 more
openaire   +2 more sources

Cathepsin-B activity in otosclerosis

Archives of Oto-Rhino-Laryngology, 1983
Cathepsin-B activity was determined fluorimetrically in the otosclerotic stapes footplate, the stapes superstructure, normal temporal cortical bone, and os frontale osteoma. Measurements with a synthetic substrate made determinations in individual samples possible. The cathepsin-B activity in the otosclerotic stapes footplate was one order of magnitude
O, Ribári, I, Sziklai, J G, Kiss, I, Sohár   +3 more
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Cathepsin B and glioma invasion

International Journal of Developmental Neuroscience, 1999
AbstractIncreased expression of cathepsin B has been reported in a number of human and animal tumors. This has also been observed in human gliomas where increases in cathepsin B mRNA, protein, activity and secretion parallel malignant progression. In the present study, we showed that cathepsin B was directly involved in glioma cell invasion.
L L, Demchik, M, Sameni, K, Nelson, T, Mikkelsen, B F, Sloane   +4 more
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Cathepsin L in glioma progression: Comparison with cathepsin B

Cancer Detection and Prevention, 2005
Lysosomal cysteine cathepsins have been implicated in tumor progression. This study is aimed to reveal differential expression and compare the prognostic significance of cathepsins B and L in glioma patients.The histological slides of 82 patients with primary astrocytic tumors were reviewed.
Tadej, Strojnik, Rajko, Kavalar, Miha, Trinkaus, Tamara T, Lah   +3 more
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CATHEPSIN B, CATHEPSIN C AND ARYLAMIDASE IN RABBIT CORNEA

Acta Ophthalmologica, 1982
The 3 peptide hydrolases cathepsin B, cathepsin C and arylamidase have been assayed in rabbit cornea with the use of fluorigenic derivatives of β‐naphthylamine. The optimal reaction conditions and kinetic properties are described. The assay procedures which are simple and very sensitive can be used for studying the release of these enzymes from corneal
K, Schive, G, Volden
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Cathepsin L, But Not Cathepsin B, Is a Potential Kininogenase

Biological Chemistry, 2001
Although papain-like enzymes are strongly inhibited by their natural tight-binding inhibitors of the cystatin superfamily, cathepsins B and L may still retain some residual proteolytic activity toward Z-Phe-Arg-AMC in the presence of an excess of kininogen. This activity is abolished by adding E-64 or chicken cystatin.
C, Desmazes, F, Gauthier, G, Lalmanach
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Pericellular cathepsin B and malignant progression

Cancer and Metastasis Reviews, 2003
Cathepsin B is a lysosomal cysteine protease in normal cells and tissues. In malignant tumors and premalignant lesions, the expression of cathepsin B is highly upregulated and the enzyme is secreted and becomes associated with the cell surface. Increases in expression are mediated at many levels ranging from gene amplification to increased stability of
Stefanie, Roshy, Bonnie F, Sloane, Kamiar, Moin   +2 more
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Cathepsin B in the rat eye

Graefe's Archive for Clinical and Experimental Ophthalmology, 2003
Cathepsin B is a mammalian cysteine protease. The enzyme has been suggested to participate in the patophysiological processes of keratoconus as well as in the corneal response to infectious agents. This study describes the localization of cathepsin B in the rat eye.Cathepsin B was identified in rat ocular tissues by Western blotting and ...
Johan, Wassélius, Hanna, Wallin, Magnus, Abrahamson, Berndt, Ehinger   +3 more
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Cerebrospinal fluid cathepsin B and S

Neurological Sciences, 2012
Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin
Elin, Nilsson, Constantin, Bodolea, Torsten, Gordh, Anders, Larsson   +3 more
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