Results 261 to 270 of about 25,778,187 (334)

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Neutral pH-Selective Inhibition of Cytosolic Cathepsin B: A Novel Drug Targeting Strategy for Traumatic Brain Injury and Alzheimer's Disease. [PDF]

ACS Chem Biol
Hook V, Podvin S, Yoon MC, Phan VV, Florio J, Spencer B, Mosier C, Cheng A, Ahuett S, Almaliti J, Gerwick WH, Rissman RA, O'Donoghue AJ.   +12 more
europepmc   +1 more source

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Comparative Enzymatic and Stability Assays Reveal GPLG as an Effective Cathepsin B Cleavable Linker for Tumor-Targeting Drug Conjugates. [PDF]

ACS Omega
Cazzaniga G, Zambra M, Bongiolo S, Prpić H, Fasola E, Arrigoni F, Piarulli U, Gazzola S.   +7 more
europepmc   +1 more source

Decoding host–microbial dynamics in peri‐implantitis: Ecosystem‐specific experimental models

Periodontology 2000, EarlyView.
Abstract Background Peri‐implantitis is an inflammatory disease arising within a unique host–microbial–biomaterial ecosystem. Unlike periodontitis, peri‐implant tissues lack a periodontal ligament and epithelial junction integrity and interface with metal oxides on titanium surfaces.
Georgios A. Kotsakis, Davi Araújo, Asaf Wilensky, Juliana Girón Bastidas, Stella Alimperti, Flavia Pirih   +5 more
wiley   +1 more source

Cathepsin B-dependent glycolysis contributes to reduced renal uric acid excretion in hyperuricemia. [PDF]

Commun Biol
Lin H, Nie L, Wu D, Zhang D, Peng R, Tao S, Ye Z, Zhu S, Ye M, Xiao J.   +9 more
europepmc   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells. [PDF]

Front Cell Dev Biol
Casali C, Gaiaschi L, Pelloni E, Gola F, Cavallo M, Milanesi G, Ravera M, Biggiogera M, De Luca F, Bottone MG.   +9 more
europepmc   +1 more source

Clinically relevant intra‐articular corticosteroid doses impair equine osteoclast function in vitro

Veterinary Surgery, EarlyView.
Abstract Objective To assess the effects of clinically relevant doses of commonly employed intra‐articular corticosteroids—specifically, triamcinolone acetonide (TCA), methylprednisolone acetate (MPA), and combination of betamethasone acetate and betamethasone sodium phosphate (BM)—on equine osteoclasts.
Gwladys Malek, Louis Kamus, Hélène Richard, Guy Beauchamp, Sheila Laverty   +4 more
wiley   +1 more source

Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior. [PDF]

Commun Biol
Xie Z, Yang Q, Lan F, Kong W, Zhao S, Sun J, Yan Y, Quan Z, Bai Z, Qing H, Mao J, Ni J.   +11 more
europepmc   +1 more source