Results 281 to 290 of about 25,778,187 (334)
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Biochimica et Biophysica Acta (BBA) - General Subjects, 2003
Active cathepsin B has been found in cell extract and medium of human osteoblast-like cells and MG-63 cells. The released form is stable at neutral and alkaline pH and, in both cell types, intracellular and extracellular cathepsin B activities are increased by interleukin-1 beta (IL-1beta) and parathyroid hormone (PTH).
Aisa M. C. +3 more
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Active cathepsin B has been found in cell extract and medium of human osteoblast-like cells and MG-63 cells. The released form is stable at neutral and alkaline pH and, in both cell types, intracellular and extracellular cathepsin B activities are increased by interleukin-1 beta (IL-1beta) and parathyroid hormone (PTH).
Aisa M. C. +3 more
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Current Medicinal Chemistry, 2006
Cathepsin B is an abundant and ubiquitously expressed cysteine peptidase of the papain family. It is involved in many physiological processes, such as remodeling of the extracellular matrix (wound healing), apoptosis, and activation of thyroxine and renin.
R, Frlan, S, Gobec
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Cathepsin B is an abundant and ubiquitously expressed cysteine peptidase of the papain family. It is involved in many physiological processes, such as remodeling of the extracellular matrix (wound healing), apoptosis, and activation of thyroxine and renin.
R, Frlan, S, Gobec
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Cathepsin L, But Not Cathepsin B, Is a Potential Kininogenase
Biological Chemistry, 2001Although papain-like enzymes are strongly inhibited by their natural tight-binding inhibitors of the cystatin superfamily, cathepsins B and L may still retain some residual proteolytic activity toward Z-Phe-Arg-AMC in the presence of an excess of kininogen. This activity is abolished by adding E-64 or chicken cystatin.
C, Desmazes, F, Gauthier, G, Lalmanach
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Cathepsin B in Human Leukocytes
cclm, 1998Abstract We have applied a method using the fluorigenic substrate benzoloxycarbonyl-Arg-Arg-amido-4-methylcoumarin to measure cathepsin B, a thiol proteinase, in homogenates of human leukocytes. Data like pH optimum, stability, influence of thiol groups and effects of thiol proteinase inhibitors, lack of binding to Concanavalin A and ...
den Tandt, W., Scharpe, S.
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Journal of Controlled Release, 2019
Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have
M. Shim +12 more
semanticscholar +1 more source
Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have
M. Shim +12 more
semanticscholar +1 more source
Cathepsin L in glioma progression: Comparison with cathepsin B
Cancer Detection and Prevention, 2005Lysosomal cysteine cathepsins have been implicated in tumor progression. This study is aimed to reveal differential expression and compare the prognostic significance of cathepsins B and L in glioma patients.The histological slides of 82 patients with primary astrocytic tumors were reviewed.
Tadej, Strojnik +3 more
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CATHEPSIN B, CATHEPSIN C AND ARYLAMIDASE IN RABBIT CORNEA
Acta Ophthalmologica, 1982The 3 peptide hydrolases cathepsin B, cathepsin C and arylamidase have been assayed in rabbit cornea with the use of fluorigenic derivatives of β‐naphthylamine. The optimal reaction conditions and kinetic properties are described. The assay procedures which are simple and very sensitive can be used for studying the release of these enzymes from corneal
K, Schive, G, Volden
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Cathepsin-B activity in otosclerosis
Archives of Oto-Rhino-Laryngology, 1983Cathepsin-B activity was determined fluorimetrically in the otosclerotic stapes footplate, the stapes superstructure, normal temporal cortical bone, and os frontale osteoma. Measurements with a synthetic substrate made determinations in individual samples possible. The cathepsin-B activity in the otosclerotic stapes footplate was one order of magnitude
O, Ribári +3 more
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Cathepsin B and glioma invasion
International Journal of Developmental Neuroscience, 1999AbstractIncreased expression of cathepsin B has been reported in a number of human and animal tumors. This has also been observed in human gliomas where increases in cathepsin B mRNA, protein, activity and secretion parallel malignant progression. In the present study, we showed that cathepsin B was directly involved in glioma cell invasion.
L L, Demchik +4 more
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Graefe's Archive for Clinical and Experimental Ophthalmology, 2003
Cathepsin B is a mammalian cysteine protease. The enzyme has been suggested to participate in the patophysiological processes of keratoconus as well as in the corneal response to infectious agents. This study describes the localization of cathepsin B in the rat eye.Cathepsin B was identified in rat ocular tissues by Western blotting and ...
Johan, Wassélius +3 more
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Cathepsin B is a mammalian cysteine protease. The enzyme has been suggested to participate in the patophysiological processes of keratoconus as well as in the corneal response to infectious agents. This study describes the localization of cathepsin B in the rat eye.Cathepsin B was identified in rat ocular tissues by Western blotting and ...
Johan, Wassélius +3 more
openaire +2 more sources