Results 241 to 250 of about 25,778,187 (334)

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Targeting Cathepsin B-mediated pyroptosis in fibroblasts alleviate ultraviolet-induced skin inflammation and injury. [PDF]

Cell Commun Signal
Yao Z, Lu L, Yu M, Wang H, Shi Y, Ying J, Yu X, Xu Q, Zhang Z, Zhang S, Li Y, Wu Y, Zhu H, Jiang H.   +13 more
europepmc   +1 more source

Intratumoral Administration of Recombinant Murine Interleukin‐12 Prevents Tumor Progression and Bone Invasion

Oral Diseases, EarlyView.
ABSTRACT Objective Oral squamous cell carcinoma (OSCC) frequently invades the mandibular bone, leading to metastasis and poor prognosis. This study aimed to evaluate the therapeutic effects of locally administered interleukin‐12 (IL‐12) using an immunocompetent mouse model mimicking the clinical features of mandibular bone invasion. Methods The effects
Shun Kasahara, Miki Kashiwagi, Toshihiro Inubushi, Akinari Sugauchi, Wu Deyong, Kyoko Kurioka, Kazuaki Miyagawa, Takuma Matsuda, Soju Seki, Mikihiko Kogo, Susumu Tanaka, Toshihiro Uchihashi   +11 more
wiley   +1 more source

Comprehensive Analysis of Cathepsin Genes in Hemiptera: Functional Characterization of the Venomous Cathepsin B from <i>Sycanus bifidus</i>. [PDF]

Insects
Liang W, Liu S, Wang Y, Wu C, Wang W, Zhu J.   +5 more
europepmc   +1 more source

Targeting the miR-96-5p/Cathepsin B Pathway to Alleviate Neuron-Derived Neuroinflammation in Alzheimer's Disease. [PDF]

MedComm (2020)
Zheng K, Huang HZ, Liu D, Brazhe N, Chen J, Zhu LQ.   +5 more
europepmc   +1 more source

Muscle Cathepsin B Treatment Improves Behavioral and Neurogenic Deficits in a Mouse Model of Alzheimer's Disease. [PDF]

Aging Cell
Pinto A, Haytural H, Loss CM, Alvarez C, Ertas A, Curtis O, Williams AR, Murphy G, Salleng KJ, Gografe S, Visavadiya NP, Khamoui AV, Altıntaş A, Kafri T, Barres R, Deshmukh AS, van Praag H.   +16 more
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Cathepsin B hyperactivation facilitates exosome release of CVB3 particles and exacerbation of acute pancreatitis by impairing lysosomal integrity and acidification. [PDF]

mBio
Liang T, Zhang Z, Xu L, Sun Z, Xu W.
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Lysosomal targeting of liposomes with acidic pH and Cathepsin B induces protein aggregate clearance. [PDF]

Cell Commun Signal
Jeon M, Kim DE, Choi SY, Kim S, Kim S, Lee H, Kim H.   +6 more
europepmc   +1 more source