Results 291 to 300 of about 12,525,351 (366)

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Unveiling Cathepsin B inhibition with repurposed drugs for anticancer and anti-Alzheimer's drug discovery. [PDF]

PLoS One
Alrouji M, Yasmin S, Yasmin S, Alshammari MS, Alhumaydhi FA, Sharaf SE, Shahwan M, Shamsi A.   +7 more
europepmc   +1 more source

Non-canonical caspase-8 activation by cathepsin B drives anti-inflammatory human macrophage polarization [PDF]

Arnaud Jacquel, Emeline Kerreneur, Paul Chaintreuil, Constance Delaby, Sonia Boulakirba, Maxence Bourgoin, Morgane Fajolles, Cécile Favreau, Adèle Rivault, Juba Bennour, Nathalie Droin, Jean‐François Peyron, Johanna Chiche, Thomas Cluzeau, Michaël Loschi, Guillaume Robert, Patrick Auberger   +16 more
openalex   +1 more source

Unraveling Lysosomal Exocytosis: From Molecular Mechanisms to Physiological Functions

Traffic, Volume 27, Issue 1, March 2026.
Lysosomal exocytosis is propelled by specific molecular mechanisms that direct its microtubule‐dependent transport and subsequent fusion with the plasma membrane. This process fulfills essential physiological functions such as plasma membrane repair, maintenance of cellular homeostasis, and participation in signal transduction.
Shanshan Jiang, Jingyi Fu, Shan Li, Zehui Li, Qirui Zhao, Yuqi Yin, Mei Yang, Yonghua Wang   +7 more
wiley   +1 more source

Paxillin promotes the invasion and migration of polyploid giant cancer cells with daughter cells after arsenic trioxide treatment by regulating the expression of cathepsin B/D. [PDF]

J Cancer
Wang J, Wang X, Li N, Liu K, Zhang S.
europepmc   +1 more source

Peptide and Drug‐Protected Gold Nanoclusters as Promising Biomaterials: Synthesis, Properties, and Applications

Aggregate, Volume 7, Issue 2, February 2026.
The integration of atomically precise gold nanoclusters with peptides or drugs represents a cutting‐edge class of nanomaterials in the biomedical field, owing to their unique physicochemical properties such as water solubility, excellent biocompatibility, low toxicity, and good renal clearance.
Rebeca Garcia Moura, M. Terêsa Machini, Rongchao Jin   +2 more
wiley   +1 more source

Inhibiting cathepsin B alleviates acute lung injury caused by sepsis through suppression of pyroptosis in lung epithelial cells. [PDF]

Eur J Med Res
Zhang X, Deng Z, Zhang X, Xu Q, Liu L, Yang D, Guo Z.   +6 more
europepmc   +1 more source

Elucidation of Proteoforms of Chinese Hamster Ovary (CHO) Phospholipase B‐Like 2 (PLBL2) Captured From a Monoclonal Antibody

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 406-419, February 2026.
A platform approach to the affinity capture and enrichment of host cell proteins to enable their subsequent deep characterization and elucidation of variants or proteoforms (e.g., molecular size variants, charge variants, glycoforms, etc.). ABSTRACT Removing host cell proteins (HCPs) during biotherapeutic manufacturing is essential to ensure patient ...
Michael E. Dolan, Lei (Leo) Wang, Alexander Tedeschi, Yan Wang, Christopher Barton, Sheldon F. Oppenheim, Zhaohui Sunny Zhou   +6 more
wiley   +1 more source

Embryo-Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis. [PDF]

Adv Sci (Weinh)
Li MY, Wu Y, Tang HL, Wang Y, Li B, He YY, Yan GJ, Yang ZM.   +7 more
europepmc   +1 more source

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source