Results 81 to 90 of about 25,778,187 (334)

Cathepsin B launches an apoptotic exit effort upon cell death-associated disruption of lysosomes

Cell Death Discovery, 2016
The release of cathepsin proteases from disrupted lysosomes results in lethal cellular autodigestion. Lysosomal disruption-related cell death is highly variable, showing both apoptotic and necrotic outcomes.
Magnus William de Castro, G. Bunt, FS Wouters   +2 more
semanticscholar   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Release of cathepsin-B in cytosol causes cell death in acute pancreatitis

Gastroenterology, 2016
BACKGROUND & AIMS Experimental studies in acute pancreatitis (AP) suggest strong association of acinar cell injury with cathepsin-B dependent intracellular activation of trypsin.
R. Talukdar, Archana Sareen, Hong-Yan Zhu, Zuobiao Yuan, A. Dixit, Hassam Cheema, J. George, Usman Barlass, R. Sah, Sushil Garg, Sulagna Banerjee, P. Garg, V. Dudeja, R. Dawra, A. Saluja   +14 more
semanticscholar   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Journal of Experimental Medicine, 2016
Kanneganti and collaborators propose that the lysosomal protease cathepsin B provides a checkpoint for activation of the transcription factor TFEB and lysosomal biogenesis and explore the impact of this pathway on host defense against bacterial infection.
Xiao-Peng Qi, Si-Ming Man, R. K. Subbarao Malireddi, Rajendra Karki, Christopher R. Lupfer, Prajwal Gurung, G. Neale, Clifford S. Guy, M. Lamkanfi, T. Kanneganti   +9 more
semanticscholar   +1 more source

ANGPTL4 Exacerbates Renal Injury in Diabetic Kidney Disease by Impairing Podocyte Lipophagy via Compromised Lysosomal Degradative Function

Advanced Science, EarlyView.
In diabetic kidney disease, elevated podocyte ANGPTL4 is linked to reduced TFEB nuclear localization and compromised lysosomal degradative function. These changes impair podocyte lipophagy and promote lipid‐droplet accumulation and podocyte injury, which may contribute to renal injury progression.
Xiaojing Liu, Shimin Jiang, Zhenkun Yang, Shunlai Shang, Jiayi Li, Guming Zou, Cheng Zhou, Wenge Li   +7 more
wiley   +1 more source

Downregulation of uPAR and cathepsin B induces apoptosis via regulation of Bcl-2 and Bax and inhibition of the PI3K/Akt pathway in gliomas.

PLoS ONE, 2010
BackgroundGlioma is the most commonly diagnosed primary brain tumor and is characterized by invasive and infiltrative behavior. uPAR and cathepsin B are known to be overexpressed in high-grade gliomas and are strongly correlated with invasive cancer ...
Ramarao Malla, Sreelatha Gopinath, Kiranmai Alapati, Christopher S Gondi, Meena Gujrati, Dzung H Dinh, Sanjeeva Mohanam, Jasti S Rao   +7 more
doaj   +1 more source

CD4-independent human immunodeficiency virus infection involves participation of endocytosis and cathepsin B. [PDF]

PLoS ONE, 2011
During a comparison of the infectivity of mNDK, a CD4-independent human immunodeficiency virus type 1 (HIV-1) strain, to various cell lines, we found that HeLa cells were much less susceptible than 293T and TE671 cells.
Hiroaki Yoshii, Haruka Kamiyama, Kensuke Goto, Kazunori Oishi, Nobuhiko Katunuma, Yuetsu Tanaka, Hideki Hayashi, Toshifumi Matsuyama, Hironori Sato, Naoki Yamamoto, Yoshinao Kubo   +10 more
doaj   +1 more source

Characterisation of Cathepsin B and Collagenolytic Cathepsin from Human Placenta [PDF]

European Journal of Biochemistry, 1978
1. Human placental cathepsin B and collagenolytic cathepsin were separated by chromatography on columns of Amberlite CG-50. Collagenolytic cathepsin was partially purified by chromatography on DEAE-Sephadex (A-50) and Sephadex G-100. Cathepsin B was purified by chromatography on CM-cellulose and Sephadex G-100. 2.
P, Evans, D J, Etherington
openaire   +2 more sources

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source