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Inhibitors of cathepsin C (dipeptidyl peptidase I)
Expert Opinion on Therapeutic Patents, 2010Cathepsin C (dipeptidyl peptidase I) plays a key role in the activation of several degradative enzymes linked to tissue destruction in inflammatory diseases. Thus, cathepsin C inhibitors could potentially be effective therapeutics for the treatment of such diseases as chronic obstructive pulmonary disease and cystic fibrosis.Although this article ...
Dramane I, Laine, Jakob, Busch-Petersen
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Cystatin C and cathepsins in cardiovascular disease
Frontiers in Bioscience, 2008Cystatin C and cathepsins could play a role in almost all processes involved in atherosclerotic lesion formation by their degradation of extracellular matrix proteins and apolipoprotein B100, the protein moiety of LDL. Several cysteine cathepsins are upregulated in human lesions accompanied by a decrease in cystatin C, the major inhibitor of cysteine ...
Eva, Bengtsson +2 more
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Properties of cathepsin C from rat liver
Biochimica et Biophysica Acta (BBA) - Enzymology, 1972Abstract 1. 1. Rat liver cathepsin C (EC 3.4.4.9) was purified 1790-fold over the homogenate activity by a purification scheme that combined the techniques of centrifugation, acid precipitation, (NH4)2SO4 precipitation, and Sephadex G-200, DEAE-cellulose, and CM-cellulose column fractionations. 2. 2. The specific activity of the most purified
F L, Huang, A L, Tappel
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Cathepsin C: structure, function, and pharmacological targeting
Rare Disease and Orphan Drugs Journal, 2023Cathepsin C is a papain-like cysteine peptidase known primarily for its involvement in the activation of serine peptidases in neutrophils and other immune cells. Its critical role in this process qualifies cathepsin C as a target for the treatment of inflammatory diseases, and its most advanced inhibitor, brensocatib (Insmed), is currently in phase 3 ...
Milena Stojkovska Docevska +1 more
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Cathepsin C promotes the progression of periapical periodontitis
Science Bulletin, 2020Although the role of cathepsin C (Cat C) in inflammation is gradually being elucidated, its function in periapical periodontitis, which is one of the most common infectious diseases worldwide, has not been studied. This study evaluated a surgically-induced model of periapical periodontitis in cathepsin C (Cat C) knock-down (KD) mice, which was ...
Wei, Yin +10 more
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SYNTHESIS OF PHOSPHONO DIPEPTIDES, INHIBITORS OF CATHEPSIN C
Phosphorus, Sulfur, and Silicon and the Related Elements, 1998Abstract Phosphono dipeptides containing glycine, glycylglycine or L-alanine at N-termini and racemic phosphonic acid analogues of aromatic amino acids, as well as racemic alicyclic aminophosphonates, exhibit moderate inhibitory activity towards cathepsin C.
Malgorzata Pawelczap +2 more
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Cathepsins and cystatin C in atherosclerosis and obesity
Biochimie, 2010Given the increasing prevalence of human obesity worldwide, there is an urgent need for a better understanding of the molecular mechanisms linking obesity to metabolic and cardiovascular diseases. Our knowledge is nevertheless limited regarding molecules linking adipose tissue to downstream complications.
Jean-Charles, Lafarge +3 more
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Cathepsin C Gene Variants in Aggressive Periodontitis
Journal of Dental Research, 2008Cathepsin C ( CTSC) mutations are known to cause Papillon-Lefèvre syndrome. The aim of this study was to examine the association of CTSC genotype with susceptibility to non-syndromic aggressive periodontitis. The CTSC gene was analyzed in 110 persons with generalized aggressive periodontitis in comparison with 78 control individuals, after identifying
B, Noack +6 more
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Molecular Medicine Today, 2000
Why are some individuals predisposed to dental caries whereas others, despite poor dental hygiene, have strong, healthy and good-looking teeth? The answer intuitively must include a genetic predisposition in addition to specific interactions with the environment.Toomes et al.1xLoss-of-function mutations in the cathepsin C gene result in periodontal ...
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Why are some individuals predisposed to dental caries whereas others, despite poor dental hygiene, have strong, healthy and good-looking teeth? The answer intuitively must include a genetic predisposition in addition to specific interactions with the environment.Toomes et al.1xLoss-of-function mutations in the cathepsin C gene result in periodontal ...
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Chromatographic purification of the thiol enzyme cathepsin C
Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects, 1964Abstract Cathepsin C (EC 3.4.4.9), an intracellular peptidase with an essential thiol group, was isolated from beef spleen and purified to a high degree—although not completely—by ion-exchange chromatography and gel filtration. In the ultracentrifuge, the purest preparation obtained showed two peaks, the heavier of which contained about 60% of the ...
R J, PLANTA, M, GRUBER
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