Cathepsin K in lymphangioleiomyomatosis: LAM cell-fibroblast Interactions enhance protease activity by extracellular acidification [PDF]
The American Journal of Pathology, 2017 Lymphangioleiomyomatosis (LAM) is a rare disease in which clonal ‘LAM’ cells infiltrate the lungs and lymphatics. In association with recruited fibroblasts, LAM cells form nodules adjacent to lung cysts. It is assumed LAM nodule derived proteases lead to
Akhenblit +53 more
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Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K [PDF]
Molecules, 2023 Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed.
Shun Sato +6 more
doaj +2 more sources
Serum and Synovial Levels of Cathepsin G and Cathepsin K in Patients with Psoriatic Arthritis and Their Correlation with Disease Activity Indices [PDF]
Diagnostics, 2023 This retrospective case-control study examined the relationship between the serum and synovial levels of cathepsin G (CatG) and cathepsin K (CatK) in patients with psoriatic arthritis (PsA) and their association with disease activity.
Stanislava Dimitrova Popova-Belova +3 more
doaj +2 more sources
PINK1-mediated mitophagy contributes to glucocorticoid-induced cathepsin K production in osteocytes [PDF]
Journal of Orthopaedic Translation, 2023 Background: Glucocorticoid (GC) is one of frequently used anti-inflammatory agents, but its administration is unfortunately accompanied with bone loss.
Jun Yuan +8 more
doaj +2 more sources
Cathepsin K Mutation-A Subtle Clinical Presentation. [PDF]
J Endocr Soc, 2022 Abstract Context Pyknodysostosis is an uncommon inherited disorder associated with consanguinity, often presenting with sclerotic bone disease, short stature, dysmorphic features, and recurrent fragility fractures at an early age. Case
Nandipati VS +7 more
europepmc +3 more sources
Synthesis and Biological Evaluation of Novel Piperidine-3-Carboxamide Derivatives as Anti-Osteoporosis Agents Targeting Cathepsin K [PDF]
MoleculesA series of novel piperidamide-3-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against cathepsin K. Among these derivatives, compound H-9 exhibited the most potent inhibition, with an IC50 value of 0.08 µM ...
Yali Wang +6 more
doaj +2 more sources
Review of Cathepsin K Inhibitor Development and the Potential Role of Phytochemicals [PDF]
MoleculesCathepsin K plays a pivotal role in bone resorption and has emerged as a prominent therapeutic target for treating bone-related diseases such as osteoporosis.
Dong Oh Moon
doaj +2 more sources
Cathepsin K inhibition induces Raptor destabilization and mitochondrial dysfunction via Syk/SHP2/Src/OTUB1 axis-mediated signaling [PDF]
Cell Death and Disease, 2023 The Raptor signaling pathway is a critical point of intervention in the invasion and progression of cancer. The non-receptor tyrosine kinase Src-mediated phosphorylation of OTUB1-Y26 plays a critical role in Raptor stabilization, whereas cathepsin K ...
Seung Un Seo +2 more
doaj +2 more sources
Cathepsin K inhibition promotes efficient differentiation of human embryonic stem cells to mature cardiomyocytes by mediating glucolipid metabolism and cellular energy homeostasis [PDF]
Stem Cell Research & TherapyBackground and aim Generation of functional cardiomyocytes from human pluripotent stem cells (hPSCs) offers promising applications for cardiac regenerative medicine.
Ying Wang +5 more
doaj +2 more sources
Cathepsin K inhibition by VBX1000 alleviates canine periodontitis [PDF]
Frontiers in Veterinary ScienceIntroductionThe efficacy and safety of a novel cathepsin K inhibitor, VBX1000, were evaluated in client-owned dogs suffering from periodontal disease.MethodsThis open-label study recruited twenty dogs (n = 20) with at least 3 teeth at stage 2 or 3 of ...
Jerzy Gawor +9 more
doaj +2 more sources