Sustained release of cathepsin D/cathepsin K from injectable hydrogel microspheres in anti-photoaging [PDF]
Materials Today BioThere have been various interventions for photoaging skin, such as retinoic acid treatment and laser therapy. However, more precise, secure, and effective technologies and materials were still need to be explored. Cathepsin D (CTSD) repairs the epidermal
Wenyi Hou +9 more
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Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin V in Osteoclasts Cultured In Vitro [PDF]
International Journal of Dentistry, 2023 Introduction. Bisphosphonates are widely used in the treatment of osteoporosis; however, they are associated with the serious adverse event of bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Aim. The aim of this study is to assess the effects of
Arturo Bautista-Carbajal +5 more
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Cathepsin K cleavage of angiopoietin-2 creates detrimental Tie2 antagonist fragments in sepsis [PDF]
The Journal of Clinical InvestigationElevated angiopoietin-2 is associated with diverse inflammatory conditions, including sepsis, a leading global cause of mortality. During inflammation, angiopoietin-2 antagonizes the endothelium-enriched receptor Tie2 to destabilize the vasculature.
Takashi Suzuki +13 more
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Cathepsin K is present in invasive oral tongue squamous cell carcinoma in vivo and in vitro. [PDF]
PLoS ONE, 2013 OBJECTIVES: Cathepsin K, a lysosomal cysteine protease, is expressed in the tumor microenvironment (TME) of skin carcinoma, but nothing is known about cathepsin K in oral tongue squamous cell carcinoma (OTSCC).
Carolina C Bitu +10 more
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The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer
Molecules, 2020 (1) Background: Cathepsin K has been found overexpressed in several malignant tumors. However, there is little information regarding the involvement of Cathepsin K in non-small cell lung cancer (NSCLC).
Hui Yang +5 more
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Scientific Reports, 2022 Persistent/chronic inflammatory pain involves multiple pathophysiological mechanisms and is far more complex than acute/momentary pain. Current therapeutics for chronic inflammatory pain are often not effective because the etiology responsible for the ...
Maha Paracha +6 more
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Frontiers in Endocrinology, 2020 Cathepsin K plays an important role in bone resorption. The reports of the association of serum cathepsin K with bone mineral density (BMD) and bone turnover markers are conflicting and the role of serum cathepsin K as a bone turnover marker is unclear ...
Li-hong Gao +3 more
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Cathepsin K in Melanoma Invasion [PDF]
Journal of Investigative Dermatology, 2008 Cathepsin K (catK) is a lysosomal cysteine protease with strong collagenolytic activity that mediates bone resorption in osteoclasts. Recently, catK expression has been reported in skin and lung fibroblasts, which suggests a role in maintaining homeostasis of the extracellular matrix outside of bone.
Quintanilla-Dieck, Maria J. +4 more
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Status and future directions of anti-metastatic cancer nanomedicines for the inhibition of cathepsin L [PDF]
, 2020 Angiogenesis, tissue invasion and metastasis in the tumour microenvironment are all critical hallmarks of cancer. Upregulation of cathepsin L plays an important role in angiogenesis and metastasis through its ability to degrade the extracellular matrix ...
Pranjol, Md Zahidul I +3 more
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The Role of DmCatD, a Cathepsin D-Like Peptidase, and Acid Phosphatase in the Process of Follicular Atresia in Dipetalogaster maxima (Hemiptera: Reduviidae), a Vector of Chagas' Disease [PDF]
, 2015 In this work, we have investigated the involvement of DmCatD, a cathepsin D-like peptidase, and acid phosphatase in the process of follicular atresia of Dipetalogaster maxima, a hematophagous insect vector of Chagas' disease. For the studies, fat bodies,
Canavoso, Lilian Etelvina +3 more
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