Cathepsin K Knockout Mitigates High-Fat Diet–Induced Cardiac Hypertrophy and Contractile Dysfunction [PDF]
, 2014 The cysteine protease cathepsin K has been implicated in pathogenesis of cardiovascular disease. We hypothesized that ablation of cathepsin K protects against obesity-associated cardiac dysfunction.
Dolence, Julia +5 more
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Circulating cathepsin K and cystatin C in patients with cancer related bone disease: Clinical and therapeutic implications [PDF]
, 2007 The clinical significance of serum cathepsin K and cystatin C was assessed in patients with breast cancer (BCa) or prostate cancer (PCa) with confined disease (M0) or bone metastasis (BM).
CRESCIMANNO, Marilena +3 more
core +1 more source
Autocatalytic Activation of Human Cathepsin K [PDF]
Journal of Biological Chemistry, 1997 The in vitro activation of the recombinant purified human cathepsin K (EC 3.4.22.38) was examined by mutagenesis. Cathepsin K was expressed as a secreted proenzyme using baculovirus-infected Sf21 insect cells. Spontaneous in vitro activation of procathepsin K occurred at pH 4 and was catalyzed by exogenous mature cathepsin K.
M S, McQueney +9 more
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Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells [PDF]
, 2014 Formation of the atherosclerotic intima must involve altered metabolism of the elastin-rich arterial extracellular matrix. Proteases potentially involved in these processes remain unclear.
Chapman, H A +4 more
core +1 more source
Cathepsin-k expression in pulmonary lymphangioleiomyomatosis [PDF]
Modern Pathology, 2009 Lymphangioleiomyomatosis is a rare and progressive lung cystic disease, caused by the infiltration of lung parenchyma by mesenchymal cells characterized by co-expression of contractile proteins and melanocytic markers. The pathogenesis of lymphangioleiomyomatosis is determined by mutations affecting tuberous sclerosis complex (TSC) genes, with eventual
CHILOSI, Marco +6 more
openaire +3 more sources
The effect of cathepsin K deficiency on airway development and TGF-β1 degradation
Respiratory Research, 2011 Background Cathepsin K, a cysteine protease predominantly expressed in osteoclasts, is a major drug target for the treatment of osteoporosis. Recent findings, however, indicate that cathepsin K is also involved in non-skeletal metabolism.
Saftig Paul +4 more
doaj +1 more source
A bioavailable cathepsin S nitrile inhibitor abrogates tumor development [PDF]
, 2016 BACKGROUND: Cathepsin S has been implicated in a variety of malignancies with genetic ablation studies demonstrating a key role in tumor invasion and neo-angiogenesis.
Burden, Roberta E +4 more
core +1 more source
Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization [PDF]
, 2007 rom the identification of genes to the characterization of their functions and interactions. Developmental biologists have long used whole mount in situ hybridization (WISH) to determine gene expression patterns, as a vital tool for formulating and ...
Davis +7 more
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Cathepsin K knockout protects against cardiac dysfunction in diabetic mice
Scientific Reports, 2017 Diabetes is a major risk factor for cardiovascular disease and the lysosomal cysteine protease cathepsin K plays a critical role in cardiac pathophysiology.
Rui Guo +5 more
doaj +1 more source
Respiratory Research, 2011 Background Remodeling of lung tissues during the process of granuloma formation requires significant restructuring of the extra-cellular matrix and cathepsins K, L and S are among the strongest extra-cellular matrix degrading enzymes.
Percival M David +3 more
doaj +1 more source