Results 31 to 40 of about 94,685 (278)

Characterization of Cysteine Cathepsin Expression in the Central Nervous System of Aged Wild-Type and Cathepsin-Deficient Mice

Applied Sciences, 2022
The association of cathepsin proteases in neurobiology is increasingly recognized. Our previous studies indicated that cathepsin-K-deficient (Ctsk−/−) mice have learning and memory impairments.
Denise M. T. Yu, Stephanie Dauth, Michael B. Margineanu, Valentina Snetkova, Maren Rehders, Silvia Jordans, Klaudia Brix   +6 more
doaj   +1 more source

Overexpression of cathepsin K in mice decreases collagen deposition and lung resistance in response to bleomycin-induced pulmonary fibrosis

Respiratory Research, 2008
Background Lung fibrosis is a devastating pulmonary disorder characterized by alveolar epithelial injury, extracellular matrix deposition and scar tissue formation.
Buhling Frank, Länger Florian, Hoymann Heinz-Gerd, Morko Jukka, Kiviranta Riku, Steinwede Kathrin, Srivastava Mrigank, Welte Tobias, Maus Ulrich A   +8 more
doaj   +1 more source

Bone-targeting PLGA derived lipid drug delivery system ameliorates bone loss in osteoporotic ovariectomized rats

Materials & Design, 2022
The lack of safety, efficacy, and specificity has made the delivery of anti-osteoporotic drugs at a proper dose a challenge. In our study, cathepsin K inhibitor loaded poly (D, L-lactide-co-glycolide) derived lipid hybrid nanoparticles (DNPs) were ...
Youyun Zeng, Yiding Shen, Shuyi Wu, Lei Cai, Zhen Wang, Kexin Cai, Jiating Shen, Kendrick Hii Ru Yie, Hualin Zhang, Lihua Xu, Jinsong Liu   +10 more
doaj   +1 more source

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits

BMC Neuroscience, 2011
Background Cathepsin K is a cysteine peptidase known for its importance in osteoclast-mediated bone resorption. Inhibitors of cathepsin K are in clinical trials for treatment of osteoporosis.
Oswald Julia, Avena Linda, Rehders Maren, Jordans Silvia, Sîrbulescu Ruxandra F, Dauth Stephanie, Lerchl Alexander, Saftig Paul, Brix Klaudia   +8 more
doaj   +1 more source

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Besides its physiological role in lysosomal protein breakdown, extralysosomal cathepsin B has recently been implicated in apoptotic cell death. Highly specific irreversible cathepsin B inhibitors that are readily cellpermeant should be useful tools to ...
Assfalg-Machleidt, Irmgard, Deluca, Dominga, Höhneke, Clara, Machleidt, Werner, Schaschke, Norbert, Sommerhoff, Christian P.   +5 more
core   +1 more source

Increased sclerostin associated with stress fracture of the third metacarpal bone in the Thoroughbred Racehorse [PDF]

, 2018
Objectives: The exact aetiopathogenesis of microdamage induced long bone fractures remains unknown. These fractures are likely the result of inadequate bone remodeling in response to damage.
Henson, F, Hopper, N, Singer, E
core   +2 more sources

Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer

Journal of Translational Medicine, 2011
Background Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientific studies
Platt Manu O, Chen Binbin
doaj   +1 more source

Mutant K-ras Regulates Cathepsin B Localization on the Surface of Human Colorectal Carcinoma Cells

Neoplasia: An International Journal for Oncology Research, 2003
Cathepsin B protein and activity are known to localize to the basal plasma membrane of colon carcinoma cells following the appearance of K-ras mutations. Using immunofluorescence and subcellular fractionation techniques and two human colon carcinoma cell
Dora Cavallo-Medved, Julie Dosescu, Bruce E. Linebaugh, Mansoureh Sameni, Debbie Rudy, Bonnie F. Sloane   +5 more
doaj   +1 more source

Cathepsin K: The Action in and Beyond Bone

Frontiers in Cell and Developmental Biology, 2020
Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.
Rongchen Dai, Zeting Wu, Hang Yin Chu, Jun Lu, Jun Lu, Aiping Lyu, Jin Liu, Ge Zhang   +7 more
doaj   +1 more source

Pycnodysostosis: In the Indian Population – A Case Report with Review of the Literature

Journal of Primary Care Dentistry and Oral Health, 2023
Bone disorders having different causes, such as metabolic, genetic, and environmental, are well known and each of them has a characteristic clinical and radiographic appearance.
Anuradha Yadav, Chitrang Dixit, Kajal Malhotra, C A Smriti   +3 more
doaj   +1 more source