Results 61 to 70 of about 94,685 (278)
Clinical, Cosmetic and Investigational Dermatology, 2021 Igor Aleksander Bednarski,1 Magdalena Ciążyńska,2 Jacek Kabziński,3 Ireneusz Majsterek,3 Dorota Sobolewska-Sztychny,1 Joanna Narbutt,1 Aleksandra Lesiak1 1Department of Dermatology, Pediatric Dermatology and Dermatological ...
Bednarski IA +6 more
doaj
Possible role of the phagocytic proteinases, cathepsin B and elastas, in orthotopic liver transplantation [PDF]
, 1991 Kein ...
Himmelreich, G. +5 more
core +1 more source
Advanced Healthcare Materials, EarlyView.We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente +5 more
wiley +1 more source
Preparation of recombinant lysosomal cysteine protease, cathepsin K in insect cells [PDF]
, 2009 軟骨細胞に局在するシステインプロテアーゼであるカテプシンKは,骨の差異九州に関わる酵素である。カテプシンKの阻害剤は骨粗鬆症の治療薬の候補になり得る。スクリーニングや酵素の機能を調べるためには組み換えカテプシンKを大量に作成することが必要である。我々はカイコ幼虫を用いた発現系が分泌型酵素であるカテプシンKの発現に適していると考えた。C末端にmycタグを付けたカテプシンK遺伝子をカイコ用の発現ベクターに挿入し,限界希釈法で組み換えウイルスを得た ...
Kazuya NAKAGOMI +14 more
core
Cathepsin K and Metabolic Abnormalities in Schizophrenia [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2008 To the Editor: We read with much interest in the September issue of Arteriosclerosis, Thrombosis, and Vascular Biology the article by Yang et al entitled “Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice.”1 The authors demonstrate a direct participation of cathepsin K (CatK) in mouse body weight ...
Hans-Gert, Bernstein +2 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source
Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model [PDF]
, 2017 Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental ...
Aikawa +45 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.This study evaluates 3D‐printed recombinant spider silk hydrogel eADF4(C16)‐RGD in a rat AV loop model for tissue engineering. Constructs with T17b endothelial progenitor cells showed enhanced vascularization and biodegradation. Results highlight the importance of scaffold design and cellular integration in improving vascular density and overall ...
Claire M. Weinhold +9 more
wiley +1 more source
Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
BMC Cardiovascular Disorders, 2010 Background Proteolytic degradation of Type I Collagen by proteases may play an important role in remodeling of atherosclerotic plaques, contributing to increased risk of plaque rupture.
Larsen Lise +6 more
doaj +1 more source
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]
, 2011 Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Andrew Edwards +13 more
core +1 more source