Results 111 to 120 of about 29,235,414 (292)

Advances in Aptamer Drug Delivery Systems for Treatment of Glioblastoma

Advanced Science, EarlyView.
Aptamers have remarkable recognition capacity which is suitable for assisting drug delivery for GB. This review demonstrates that aptamers have great potential as targeted therapeutic carriers, conjugated to various therapeutic carriers, using a range of conjugation strategies and chemistries.
Alexandra R. Paul, Alexandra Moreno Mitchell, Dean O'Neil, Yutong Luo, Khuloud T. Al‐Jamal   +4 more
wiley   +1 more source

In Situ Bioorthogonal Synthesis of PROTACs via Dual‐Responsive Cleavage for Synergistic Photo‐Immunotherapy

Advanced Science, EarlyView.
A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Shiqin Jian, Jiasha Wu, Fusheng Xu, Yan Zuo, Huaxing Shen, Rui Ji, Luyi Wang, Na Li, Yanting Sun, Yongsheng Yu, Yejiao Shi, Honggang Hu, Feng Xu, Dan Huang, Xiaochun Hu   +14 more
wiley   +1 more source

Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells

Data in Brief, 2015
The endo-lysosomal cysteine cathepsin L has recently been shown to have moonlighting activities in that its unexpected nuclear localization in colorectal carcinoma cells is involved in cell cycle progression (Tamhane et al., 2015) [1]. Here, we show data
Tripti Tamhane, Brit K. Wolters, Rukshala Illukkumbura, Gunhild M. Maelandsmo, Mads H. Haugen, Klaudia Brix   +5 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source

The Role of Cathepsin B in Peritoneal Fibrosis due to Peritoneal Dialysis

International Journal of Nephrology, 2019
Glucose-containing peritoneal dialysis (PD) solution causes peritoneal fibrosis (PF) characterized by accumulation of extracellular matrix (ECM) in the submesothelial layer.
Su Ah Sung, Dong Hee Kim, Kook-Hwan Oh, Sang Youb Han, Kum Hyun Han   +4 more
doaj   +1 more source

Multiplex Zymography Captures Stage-specific Activity Profiles of Cathepsins K, L, and S in Human Breast, Lung, and Cervical Cancer

Journal of Translational Medicine, 2011
Background Cathepsins K, L, and S are cysteine proteases upregulated in cancer and proteolyze extracellular matrix to facilitate metastasis, but difficulty distinguishing specific cathepsin activity in complex tissue extracts confounds scientific studies
Platt Manu O, Chen Binbin
doaj   +1 more source

Azepanone-Based Inhibitors of Human Cathepsin L

, 2016
The extension of a previously reported cathepsin K azepanone-based inhibitor template to the design and synthesis of potent and selective inhibitors of the homologous cysteine protease cathepsin L is detailed.
Thaddeus Tomaszek (2648245), Robert W. Marquis (440601), Robert E. Lee Trout (2364298), Ren Xie (1450564), Ian James (230654), Yu Ru (2665042), Maxwell D. Cummings (2170888), Shing-Mei Hwang (2665033), Simon Blake (46864), Catherine J. Gress (2648242), Jin Zeng (196246), Dennis S. Yamashita (1893913), Martha S. Head (2466190), Daniel F. Veber (2133928), Attiq Rahman (2665036), Scott Thompson (365655), Michael A. Lark (2665039), Priscilla Offen (2665045)   +17 more
core   +1 more source

New insight into the RNA interference response against cathepsin-L gene in the pea aphid, Acyrthosiphon pisum: molting or gut phenotypes specifically induced by injection or feeding treatments.

Insect Biochemistry and Molecular Biology, 2014
RNA interference (RNAi) has been widely and successfully used for gene inactivation in insects, including aphids, where dsRNA administration can be performed either by feeding or microinjection.
P. Sapountzis, G. Duport, Séverine Balmand, K. Gaget, Stéphanie Jaubert-Possamai, G. Febvay, H. Charles, Y. Rahbé, S. Colella, F. Calevro   +9 more
semanticscholar   +1 more source

Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-β-naphthylamide

BioTechniques, 2006
A method is described allowing the selective determination of four cathepsins (B, H, K, and L) in live cells. Adherently growing cells are incubated with partially selective substrates for each cathepsin (peptidic derivatives of 4-methoxy-β-naphthylamine)
Anke Rüttger, Jürgen Mollenhauer, Reik Löser, Michael Gütschow, Bernd Wiederanders   +4 more
doaj   +1 more source

Plasma cathepsin L: a prognostic marker for pancreatic cancer.

World Journal of Gastroenterology, 2014
AIM To assess the prognostic significance of cathepsin L, a cysteine protease that degrades the peri-tumoral tissue, in patients with pancreatic cancer. METHODS Plasma samples from 127 pancreatic cancer patients were analyzed for cathepsin L levels by ...
Nidhi Singh, P. Das, Surabhi Gupta, V. Sachdev, S. Srivasatava, Siddhartha Datta Gupta, R. Pandey, P. Sahni, S. Chauhan, A. Saraya   +9 more
semanticscholar   +1 more source