Results 101 to 110 of about 29,235,414 (292)

Collagenolytic Cysteine Proteinases of Bone Tissue - Cathepsin-b, (pro)cathepsin-l and a Cathepsin-l-like 70 Kda Proteinase [PDF]

, 1991
The aim of the work was to identify and characterize the cysteine proteinases of bone tissue, as these enzymes appear necessary for bone resorption. Three cysteine-dependent proteolytic activities were separated from a homogenate of mouse calvaria by a ...
Ledent, Philippe, Delaisse, JM., Vaes, Gilbert   +2 more
core  

Arrayed Magnetic Accelerator Synergistically Enhances Orthodontic Tooth Movement via Microtubule Assembly‐Mediated Periodontal Remodeling

Advanced Science, EarlyView.
Mechanical orthodontic treatment for malocclusion is limited by slow remodeling and risks due to poor biomechanical sensing. This study shows that static magnetic fields (SMFs) enhance mechanical sensation in periodontal ligament cells, promoting inflammation and osteoclast activity.
Yiling Lou, Jiwei Sun, Peng Chen, Caihong Mao, Junyuan Zhang, Haoqi Lei, Xiaoqing Han, Yaxuan Zhang, Yuheng Jiang, Yulin Jia, Bin Su, Lili Chen   +11 more
wiley   +1 more source

Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model

Journal of International Medical Research, 2019
Objectives Diabetes mellitus (DM) attenuates the development of aortic aneurysms (AA). This study investigated the expression of cathepsin L and cystatin C in a hyperglycemic environment, and the influence of these proteins on AA development.
Yang Liu, Yang Jiao, Yuxiang He, Xiangjiu Ding, Qingbo Su, Yan Zhao, Jianjun Jiang   +6 more
doaj   +1 more source

Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L

Bioorganic & Medicinal Chemistry, 2015
Upregulation of cathepsin L in a variety of tumors and its ability to promote cancer cell invasion and migration through degradation of the extracellular matrix suggest that cathepsin L is a promising biological target for the development of anti ...
Erica N. Parker, Jian-Guo Song, G. D. Kishore Kumar, Samuel O. Odutola, G. E. Chavarria, Amanda K. Charlton-Sevcik, T. Strecker, Ashleigh L. Barnes, D. Sudhan, T. Wittenborn, Dietmar W. Siemann, M. Horsman, D. Chaplin, M. Trawick, K. Pinney   +14 more
semanticscholar   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Involvement of a host Cathepsin L in symbiont‐induced cell death

MicrobiologyOpen, 2018
The cathepsin L gene of the host squid, Euprymna scolopes, is upregulated during the first hours of colonization by the symbiont Vibrio fischeri. At this time, the symbiotic organ begins cell death‐mediated morphogenesis in tissues functional only at the
Suzanne M. Peyer, Natacha Kremer, Margaret J. McFall‐Ngai   +2 more
doaj   +1 more source

Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage

Acta Pharmacologica Sinica, 2015
Aim:Cathepsin L is a lysosomal cysteine protease that plays important roles in cancer tumorigenesis, proliferation and chemotherapy resistance. The aim of this study was to determine how cathepsin L regulated the radiosensitivity of human glioma cells in
Qing-Qing Zhang, Wen-juan Wang, Jun Li, N. Yang, Gang Chen, Zhong Wang, Zhong-Qin Liang   +6 more
semanticscholar   +1 more source

Procathepsin L-specific antibodies that recognize procathepsin L but not cathepsin L [PDF]

, 1993
Procathepsin L was purified to apparent homogeneity from the culture medium of v-Ha-ras transformed NIH3T3 (Ras-NIH) cells in three steps; anion-exchange chromatography, gel nitration, and re-gel filtration.
Mitsue Takeda-Ezaki, Takeda-Ezaki, Mitsue, Eiki Kominami, Kazumi Ishidoh, Kominami, Eiki, Ishidoh, Kazumi   +5 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Adult Schistosoma mansoni express cathepsin L proteinase activity

, 1994
This report presents the deduced amino acid sequence of a novel cathepsin L proteinase from Schistosoma mansoni, and describes cathepsin L-like activity in extracts of adult schistosomes.
Dalton, John P., Harrop, Stephen A., Clough, Karen A., Brindley, Paul J., Smith, Angela M., Hole, Nicky, Kilbane, Catherine L.   +6 more
core   +1 more source