Results 81 to 90 of about 29,235,414 (292)

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

The protease cathepsin L regulates Th17 cell differentiation

Journal of Autoimmunity, 2015
Previously we reported that IL-17+ T cells, primarily IL-17+ γδ cells, are increased in mice lacking the protease inhibitor serpinB1 (serpinb1−/− mice). Here we show that serpinB1-deficient CD4 cells exhibit a cell-autonomous and selective deficiency in ...
Lifei Hou, Jessica Cooley, R. Swanson, P. Ong, R. Pike, M. Bogyo, S. T. Olson, E. Remold-O’Donnell   +7 more
semanticscholar   +1 more source

Matrix Stiffness Enhances Odontogenic Differentiation of DPSCs through Membrane Curvature Protein Baiap2‐Modulated Exosome Release

Advanced Science, EarlyView.
Matrix stiffness softening is identified as a previously underappreciated feature in deep caries. Higher stiffness drives exosome release in dental pulp stem cells through a coordinated mechanism involving PI3K–AKT‐regulated Baiap2 and kinesin‐1, thereby promoting odontogenic differentiation.
Bilun Jin, Shaojie Dong, Yue Jia, Zhao Xu, Peiqi Liu, Zhaojing Ding, Yuxin Liao, Rui Zou, Jinsong Hu, Bo Cheng, Lin Niu   +10 more
wiley   +1 more source

Effect of Low Temperature Plasma Sterilization on Myosin Degradation and Related Cathepsin Activity of Oncorhynchus mykiss

Shipin gongye ke-ji
To clarify the mechanism of the effect of low temperature plasma sterilization on the degradation of Oncorhynchus mykiss and related cathepsin activity, Oncorhynchus mykiss fillets were treated with 70 kV dielectric barrier discharge low temperature ...
Xiejun SUN, Xiaoqiao CHEN, Xiuxia LI, Jianrong LI   +3 more
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Evolutionary History of Cathepsin L (L-like) Family Genes in Vertebrates

International Journal on Biological Sciences, 2015
Cathepsin L family, an important cysteine protease found in lysosomes, is categorized into cathepsins B, F, H, K, L, S, and W in vertebrates. This categorization is based on their sequence alignment and traditional functional classification, but the ...
Jin Zhou, Yao Zhang, Qing-Yun Li, Zhong-Hua Cai   +3 more
semanticscholar   +1 more source

Molecular cloning and sequencing of cDNA for rat cathepsin L [PDF]

, 1987
A near full-length cDNA for rat cathepsin L was isolated. The deduced protein comprises 334 amino acid residues (Mr 37 685) containing a typical signal sequence (N-terminal 17 residues), pro-peptide (96 residues), and the sequence for mature cathepsin L (
Towatari, Takae, Shinobu Imajoh, Nobuhiko Katunuma, Koichi Suzuki, Kazumi Ishidoh, Takae Towatari, Suzuki, Koichi, Katunuma, Nobuhiko, Kawasaki, Hiroshi, Eiki Kominami, Imajoh, Shinobu, Kominami, Eiki, Hiroshi Kawasaki, Ishidoh, Kazumi   +13 more
core   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Participation of cathepsin L on bone resorption [PDF]

, 1993
The proteinase responsible for bone collagen degradation in osteo-resorption was examined. The bone pit formation induced by parathyroid hormone (PTH) was markedly suppressed by leupeptin, E-64 and cystatin A, while no inhibition was observed by CA-074 ...
Kakegawa, Hisao, Kamioka, Hiroshi, Kahori Tagami, Koji Sumitani, Lenarčič, Brigita, Nobuhiko Katunuma, Sumitani, Koji, Kawata, Terushige, Nikawa, Takeshi, Hiroshi Kamioka, Tagami, Kahori, Takeshi Nikawa, Marinka Drobnič-Kosorok, Vito Turk, Hisao Kakegawa, Katunuma, Nobuhiko, Brigita Lenarčič, Terushige Kawata, Drobnič-Kosorok, Marinka, Turk, Vito   +19 more
core   +1 more source