Results 181 to 190 of about 16,299,323 (310)

Quantitative Structure-Activity Relationship Study of Cathepsin L Inhibitors as SARS-CoV-2 Therapeutics Using Enhanced SVR with Multiple Kernel Function and PSO. [PDF]

Int J Mol Sci
Li S, Li Z, Zhang P, Qu A.
europepmc   +1 more source

Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.

Rheumatology, 2015
T. Weitoft, A. Larsson, V. Manivel, J. Lysholm, A. Knight, J. Rönnelid   +5 more
semanticscholar   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source

Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4⁺ T cells. [PDF]

Nat Immunol
Petrozziello E, Sayed A, Freitas JA, Federle C, Nedjic J, Ravens S, Akçabozan B, Schulz AM, Zehn D, Schmidt-Supprian M, Obst R, Prinz I, Verdoes M, Kisielow J, Reinheckel T, Straub T, Daley SR, Klein L.   +17 more
europepmc   +1 more source

Impact of the Warhead of Dipeptidyl Keto Michael Acceptors on the Inhibition Mechanism of Cysteine Protease Cathepsin L. [PDF]

ACS Catal, 2023
Fernández-de-la-Pradilla A, Royo S, Schirmeister T, Barthels F, Świderek K, González FV, Moliner V.   +6 more
europepmc   +1 more source

Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor‑β‑mediated epithelial‑mesenchymal transition.

Oncology Report, 2015
Qing-qing Zhang, Meilin Han, Wen-juan Wang, Yun-zhen Song, Gang Chen, Zhong Wang, Zhongqin Liang   +6 more
semanticscholar   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Amino acid residues 655 and 969 in the spike protein of Omicron subvariant BA.1 control use of TMPRSS2 versus Cathepsin L dependent entry pathways and cell tropism. [PDF]

PLoS One
Rocha C, Arora P, Zhang L, Sidarovich A, Graichen L, Moldenhauer AS, Pöhlmann S, Hoffmann M.   +7 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage. [PDF]

Nat Genet
Li Z, Peluffo G, Stevens LE, Qiu X, Seehawer M, Tawawalla A, Huang XY, Egri SB, Raval S, McFadden M, D'Santos CS, Papachristou E, Kingston NL, Nishida J, Evans KE, Seo JH, Clement K, Temko D, Ekram M, Li R, Rees MG, Ronan MM, Roth JA, Simeonov A, Kales SC, Rai G, Lal-Nag M, Maloney DJ, Jadhav A, Michor F, Meissner A, Balko JM, Carroll JS, Freedman ML, Jaffe JD, Papanastasiou M, Long HW, Polyak K.   +37 more
europepmc   +1 more source