Results 181 to 190 of about 29,235,414 (292)

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Cannabichromeorcin targets cathepsin L to alleviate oxidative stress-Driven airway inflammation in severe asthma. [PDF]

Redox Biol
Huang J, Chen Y, Deng Y, Hu D, Chen Y, Li Y, Xie C, Fan K, Zhu B, Gong Z, Yang J, Huang S, Peng X, Peng X, Huang B, Zhao W, Du Q, Zhao H.   +17 more
europepmc   +1 more source

Oxidative Stress Drives Cell Cycle Stalling, Apoptosis and Metabolic Suppression in Cystatin B Deficient EPM1 Patient iPSCs

Cell Proliferation, EarlyView.
CSTB deficient EPM1 iPS cells manifest increased lysosomal activity and oxidative stress, which lead to DNA damage, cell cycle defects and increased apoptosis. As a protective response, metabolism is suppressed. Image created by BioRender https://BioRender.com/t44oc6h.
Shekhar Singh, Lidiia Plotnikova, Teemu Tiukuvaara, Reetta Kälviäinen, Riikka H. Hämäläinen   +4 more
wiley   +1 more source

Identification of Cathepsin L as the Molecular Target of Hydroxychloroquine With Chemical Proteomics. [PDF]

Mol Cell Proteomics
Shang J, Hu B, Kung KK, Jiang J, Zhang Q, Wong MK, Chu H, Zhao Q.   +7 more
europepmc   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

Magnolol inhibits porcine epidemic diarrhea virus infection by suppressing cathepsin L expression <i>in vitro</i> and <i>in vivo</i>. [PDF]

J Virol
Liang Y-f, Li X, Zhu G-x, Song Y, Chen X-n, Wang H, Zhang G-h.   +6 more
europepmc   +1 more source

Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.

Proceedings of the National Academy of Sciences of the United States of America, 2005
G. Simmons, D. Gosalia, Andrew J Rennekamp, J. Reeves, S. Diamond, Paul Bates   +5 more
semanticscholar   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Ligand-Independent Activation of Notch1 by Cathepsin L Induces CUX1/p16^INK4a-Dependent Endothelial Senescence Associated With Atherosclerosis. [PDF]

Aging Cell
Wu Y, Lu L, Yan S, Du Z, Jiang D, Wu T, Wu Q, Liu J, Ebin J, Sun W, Dutta P, Tan JX, Alder JK, Li G.   +13 more
europepmc   +1 more source

Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L. [PDF]

Signal Transduct Target Ther, 2023
Xu X, Yu T, Dong L, Glauben R, Wu S, Huang R, Qumu S, Chang C, Guo J, Pan L, Yang T, Lin X, Huang K, Chen Z, Wang C.   +14 more
europepmc   +1 more source