The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte +9 more
wiley +1 more source
Fluorescence Polarization-Based High-Throughput Screening Assay for Inhibitors Targeting Cathepsin L. [PDF]
Guo K +6 more
europepmc +1 more source
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages. [PDF]
John J. Reilly +4 more
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Overall, there was good concordance between renal mass biopsy and subsequent diagnosis at nephrectomy or repeat biopsy in oncocytic renal neoplasms. Some discordant cases were reclassified as emerging tumour entities (LOT, EVT), indicating that greater recognition of these entities may help reduce diagnostic uncertainty and improve biopsy ...
Shifaa' Al Qa'qa' +4 more
wiley +1 more source
Cathepsin L as a dual-target to mitigate muscle wasting while enhancing anti-tumor efficacy of anti-PD-L1. [PDF]
Park SY +14 more
europepmc +1 more source
Cathepsin L in Bone Marrow-Derived Cells Is Required for Retinal and Choroidal Neovascularization [PDF]
Noriaki Shimada +10 more
openalex +1 more source
ABSTRACT Kudoa thyrsites is a myxosporean endoparasite that infects fish, frequently resulting in myoliquefaction, impacting the texture and eating quality of fish muscle. The aim of this study was to investigate the effects of K. thyrsites infection on the proximate composition and texture parameters of raw fillets from two South African economically ...
Sune St Clair Henning +1 more
wiley +1 more source
Correction: Dynamic expression of cathepsin L in the black soldier fly (Hermetia illucens) gut during Escherichia coli challenge. [PDF]
Chiang YR +4 more
europepmc +1 more source
Thyroglobulin processing by thyroidal proteases. Major sites of cleavage by cathepsins B, D, and L.
A D Dunn +2 more
openalex +1 more source

