Results 271 to 280 of about 16,299,323 (310)

Prognostic Impact of Cysteine Proteases Cathepsin B and Cathepsin L in Pancreatic Adenocarcinoma

Pancreas, 2004
The cysteine proteases cathepsin B (CTSB) and L (CTSL) have been implicated in tumor spread and metastatic formation. In pancreatic adenocarcinoma, the role of these proteases is not very well defined. To find out which cell types produce CTSB and CTSL and to evaluate the prognostic impact of these proteases, 70 specimens from curatively resected ...
Marco, Niedergethmann, Birgit, Wostbrock, Jörg W, Sturm, Frank, Willeke, Stefan, Post, Ralf, Hildenbrand   +5 more
openaire   +2 more sources

Neutralization of the activity of a Fasciola hepatica cathepsin L proteinase by anti‐cathepsin L antibodies

Parasite Immunology, 1994
SUMMARYFasciola hepatica secretes a cathepsin L proteinase that is suggested to play an in vivo role in immunoprotection since the enzyme can cleave host immunoglobulin. In the present report, rabbit anti‐cathepsin L IgG was shown to bind to the cathepsin L enzyme and inhibit its ability to cleave IgG molecules.
A M, Smith, C, Carmona, A J, Dowd, S, McGonigle, D, Acosta, J P, Dalton   +5 more
openaire   +2 more sources

Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases

Acta Tropica, 2006
Fasciola gigantica cathepsin-L cysteine proteinase and recombinant cathepsin L 1-D were assessed for their potential in the immuno-diagnosis of F. gigantica infection in buffaloes. A diagnostic ELISA, based on these two antigens, was developed to detect antibodies against F. gigantica in water buffaloes. Sensitivity of the ELISA was assessed using sera
O K, Raina, S C, Yadav, D, Sriveny, S C, Gupta   +3 more
openaire   +2 more sources

[Role and behavior of cathepsin B and cathepsin L in gastric cancer].

Orvosi hetilap, 1995
Cathepsin B and cathepsin L--cysteine proteinases--may play an important role in cancer invasion and metastasis. The authors determined tissue antigen concentrations of cathepsins, using the ELISA method, in 25 patients with gastric cancer (17 males, 8 females, mean age 62, range 31-84).
Herszényi L, PLEBANI, MARIO, Carraro P, De Paoli M, Roveroni G, RUGGE, MASSIMO, CARDIN, ROMILDA, Naccarato R, FARINATI, FABIO   +8 more
openaire   +2 more sources

Prospective Evaluation of Free Energy Calculations for the Prioritization of Cathepsin L Inhibitors.

Journal of Medicinal Chemistry, 2017
B. Kuhn, M. Tichy, Lingle Wang, S. Robinson, Rainer E. Martin, A. Kuglstatter, J. Benz, M. Giroud, T. Schirmeister, Robert Abel, F. Diederich, J. Hert   +11 more
semanticscholar   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly  

CATHEPSIN L

1981
H. Kirschke, H.-J. Kärgel, S. Riemann, P. Bohley   +3 more
openaire   +1 more source

A role of cathepsin L gene in innate immune response of crayfish (Procambarus clarkii)

Fish and Shellfish Immunology, 2017
L. Dai, Sheng-hui Chu, Xiao-min Yu, Yan-yan Li   +3 more
semanticscholar   +1 more source

K‐ras mutation promotes ionizing radiation‐induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway

Experimental Cell Research, 2018
Long Wang, Yi-fan Zhao, Ya-jie Xiong, Wen-juan Wang, Yao Fei, Caihong Tan, Zhongqin Liang   +6 more
semanticscholar   +1 more source

Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans

International Urology and Nephrology, 2017
Yu Cao, Xing Liu, Y. Li, Yao Lu, Huazhong Zhong, Weihong Jiang, Alex F. Chen, T. Billiar, Hong Yuan, Jingjing Cai   +9 more
semanticscholar   +1 more source