Results 41 to 50 of about 16,299,323 (310)
Potential role of cytotoxic T-lymphocyte antigen 2 alpha in secretory activity of endocrine cells in mouse adenohypophysis [PDF]
Open Veterinary Journal, 2019 The peptide hormones of the adenohypophysis are produced by proteolytic processing of their prohormone precursors. Cathepsin L is known to function as a major proteolytic enzyme involved in the production of the peptide hormones.
Claudius Luziga
doaj +1 more source
Molecular Cancer, 2010 Background Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g.
Matarrese Paola +9 more
doaj +1 more source
Chemical Science, 2018 Highly-selective fluorogenic substrate and activity-based probe for monitoring cathepsin L activity in the breast cancer cell line MDA-MB-231.
M. Poręba +10 more
semanticscholar +1 more source
Cathepsin L secretion by host and neoplastic cells potentiates invasion
OncoTarget, 2019 The presence of macrophages within breast tumors correlates with metastatic potential. These tumor-associated macrophages often take on a pro-tumorigenic (M2-like) phenotype resulting in the secretion of growth factors and proteases, including the ...
Samantha S. Dykes +2 more
semanticscholar +1 more source
Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases. [PDF]
PLoS ONE, 2012 C1A cysteine peptidases are synthesized as inactive proenzymes. Activation takes place by proteolysis cleaving off the inhibitory propeptide. The inhibitory capacity of propeptides from barley cathepsin L and B-like peptidases towards commercial and ...
Inés Cambra +3 more
doaj +1 more source
Biotechnology progress (Print), 2018 A stochastic approach of copurification of the protease Cathepsin L that results in product fragmentation during purification processing and storage is presented.
Haibin Luo +8 more
semanticscholar +1 more source
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila
Neurobiology of Disease, 2012 Endocytosis-mediated cell death is a form of degeneration displayed in several Drosophila mutants. This form of degeneration is displayed in several Drosophila mutant lines including flies lacking the eye-specific PLC (norpA).
Ronald D. Kinser, Patrick J. Dolph
doaj +1 more source
Cathepsin L and Cathepsin B Mediate Reovirus Disassembly in Murine Fibroblast Cells [PDF]
Journal of Biological Chemistry, 2002 After attachment to receptors, reovirus virions are internalized by endocytosis and exposed to acid-dependent proteases that catalyze viral disassembly. Previous studies using the cysteine protease inhibitor E64 and a mutant cell line that does not support reovirus disassembly suggest a requirement for specific endocytic proteases in reovirus entry ...
Ebert, Daniel H. +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source