Results 41 to 50 of about 29,235,414 (292)

Effect of heavy metal cations on the activity of cathepsin D (in vitro study) Effect of heavy metal cations on the activity of cathepsin D (in vitro study)

Folia Histochemica et Cytobiologica, 2012
We studied the effect of heavy metal cations: Fe 2+, Cu2+, Zn2+, Cd2+, Hg2+, Pb2+ on the activity of<br />cathepsin D in human aorta homogenate and blood serum. The concentration of cations was 1 mmol/l.
Alicja Karwowska, Radosław Łapiński, Marek Gacko, Ewa Grzegorczyk, Joanna Żurawska, Jan K. Karczewski   +5 more
doaj   +1 more source

The lysosomal protein cathepsin L is a progranulin protease

Molecular Neurodegeneration, 2017
Haploinsufficiency of GRN, the gene encoding progranulin (PGRN), causes frontotemporal lobar degeneration (FTLD), the second most common cause of early-onset dementia.
Chris W. Lee, Jeannette N. Stankowski, Jeannie Chew, C. Cook, Ying W. Lam, S. Almeida, Y. Carlomagno, K. Lau, M. Prudencio, Fen-Biao Gao, M. Bogyo, D. Dickson, L. Petrucelli   +12 more
semanticscholar   +1 more source

Cathepsin-L can resist lysis by human serum in Trypanosoma brucei brucei. [PDF]

, 2014
Closely related African trypanosomes cause lethal diseases but display distinct host ranges. Specifically, Trypanosoma brucei brucei causes nagana in livestock but fails to infect humans, while Trypanosoma brucei gambiense and Trypanosoma brucei ...
Currier, Rachel B., Taane G Clark, Horn, David, José Afonso Guerra-Assunção, Clark, Taane G., Sam Alsford, Taane G. Clark (106263), David Horn (24969), Alsford, Sam, Rachel B Currier, Rachel B. Currier (144838), Guerra-Assunção, José Afonso, Currier, Rachel B, Horn, David; id_orcid, José Afonso Guerra-Assunção (166779), Guerra-Assunção, Jose Alfonso, Sam Alsford (24967), David Horn, Clark, Taane G   +18 more
core   +1 more source

Potential role of cytotoxic T-lymphocyte antigen 2 alpha in secretory activity of endocrine cells in mouse adenohypophysis [PDF]

Open Veterinary Journal, 2019
The peptide hormones of the adenohypophysis are produced by proteolytic processing of their prohormone precursors. Cathepsin L is known to function as a major proteolytic enzyme involved in the production of the peptide hormones.
Claudius Luziga
doaj   +1 more source

Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism.

International Journal of Cardiology, 2019
The development of hypertension involves extensive arterial wall remodeling, in which cysteine proteases play an essential role. Cathepsin L/V has been reported to be a cysteine protease that is closely intertwined with the tissue inflammatory response ...
Yao Lu, Xue Sun, Li-ping Peng, Wei-Hong Jiang, Wen-Bo Li, Hong Yuan, Jingjing Cai   +6 more
semanticscholar   +1 more source

Cathepsin B inhibition interferes with metastatic potential of human melanoma: an in vitro and in vivo study

Molecular Cancer, 2010
Background Cathepsins represent a group of proteases involved in determining the metastatic potential of cancer cells. Among these are cysteinyl- (e.g. cathepsin B and cathepsin L) and aspartyl-proteases (e.g.
Matarrese Paola, Ascione Barbara, Ciarlo Laura, Vona Rosa, Leonetti Carlo, Scarsella Marco, Mileo Anna M, Catricalà Caterina, Paggi Marco G, Malorni Walter   +9 more
doaj   +1 more source

Cathepsin L secretion by host and neoplastic cells potentiates invasion

OncoTarget, 2019
The presence of macrophages within breast tumors correlates with metastatic potential. These tumor-associated macrophages often take on a pro-tumorigenic (M2-like) phenotype resulting in the secretion of growth factors and proteases, including the ...
Samantha S. Dykes, Henrietta O. Fasanya, D. Siemann   +2 more
semanticscholar   +1 more source

Structural basis for specificity of propeptide-enzyme interaction in barley C1A cysteine peptidases. [PDF]

PLoS ONE, 2012
C1A cysteine peptidases are synthesized as inactive proenzymes. Activation takes place by proteolysis cleaving off the inhibitory propeptide. The inhibitory capacity of propeptides from barley cathepsin L and B-like peptidases towards commercial and ...
Inés Cambra, David Hernández, Isabel Diaz, Manuel Martinez   +3 more
doaj   +1 more source

Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes

Chemical Science, 2018
Highly-selective fluorogenic substrate and activity-based probe for monitoring cathepsin L activity in the breast cancer cell line MDA-MB-231.
M. Poręba, Wioletta Rut, Matej Vizovišek, Katarzyna Groborz, Paulina Kasperkiewicz, D. Finlay, K. Vuori, D. Turk, B. Turk, G. Salvesen, M. Drąg   +10 more
semanticscholar   +1 more source

Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

Biotechnology progress (Print), 2018
A stochastic approach of copurification of the protease Cathepsin L that results in product fragmentation during purification processing and storage is presented.
Hai-Bin Luo, Tie Liu, Ming-Yan Cao, Alan K. Hunter, Timothy M. Pabst, Jia-Li Du, R. Field, Yu-Ling Li, William K. Wang   +8 more
semanticscholar   +1 more source