Results 71 to 80 of about 108,477 (229)
Shipin gongye ke-jiTo clarify the mechanism of the effect of low temperature plasma sterilization on the degradation of Oncorhynchus mykiss and related cathepsin activity, Oncorhynchus mykiss fillets were treated with 70 kV dielectric barrier discharge low temperature ...
Xiejun SUN +3 more
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Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy [PDF]
, 2017 Mechanisms underlying the onset and progression of nephropathy in diabetic patients are not fully elucidated. Deregulation of proteolytic systems is a known path leading to disease manifestation, therefore we hypothesized that proteases aberrantly ...
Bascands, Jean-Loup +15 more
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Procathepsin L‐specific antibodies that recognize procathepsin L but not cathepsin L [PDF]
FEBS Letters, 1993 Procathepsin L was purified to apparent homogeneity from the culture medium of v‐Ha‐ras transformed NIH3T3 (Ras‐NIH) cells in three steps; anion‐exchange chromatography, gel nitration, and re‐gel filtration. SDS‐PAGE analyses revealed that the purified samples contained only the precursor form, procathepsin L, but not the mature enzyme, cathepsin L ...
Ishidoh, Kazumi +2 more
openaire +2 more sources
N-formylpyrazolines and N-benzoylpyrazolines as potential inhibitors cathepsin L
AIMS Molecular Science, 2016 Elevated levels of cathepsins implicated in cancer, inflammation and number of degenerative diseases emphasize the investigation of potential inhibitors in search for novel chemotherapeutic agents with better efficacy.
N. Raghav, S. Garg
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Molecules, 2020 Presently, there are no approved drugs or vaccines to treat COVID-19, which has spread to over 200 countries and at the time of writing was responsible for over 650,000 deaths worldwide.
R.P. Vivek-Ananth +4 more
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Diminished Intracellular Invariant Chain Expression Following Vaccinia Virus Infection [PDF]
, 2009 Vaccinia virus (VV) has been used as a vaccine to eradicate smallpox and as a vaccine for HIV and tumors. However, the immunoevasive properties of VV, have raised safety concerns.
Blum, Janice S. +2 more
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Sokoto Journal of Medical Laboratory Science, 2020 Cathepsin L, a lysosomal endopeptidase expressed in most eukaryotic cells, is a member of the papain-like family of cysteine proteinases. This broad-spectrum protease is potent in degrading several extracellular proteins (laminins, fibronectin, collagens
Minari, J.B.* and Adelabu, M.A.
doaj
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor [PDF]
, 2011 Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
D. Brent Polk +8 more
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Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis [PDF]
, 2011 Mutations in the cathepsin D (CTSD) gene cause an aggressive neurodegenerative disease (congenital neuronal ceroid lipofuscinosis) that leads to early death. Recent evidence suggests that presynaptic abnormalities play a major role in the pathogenesis of
Andrew Edwards +13 more
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International Clinical Neuroscience Journal, 2020 Background: Juvenile neuronal ceroid lipofuscinosis (JNCL), one of the most frequent forms of the NCL storage diseases, is known to be caused by loss-of-function mutations in ceroid-lipofuscinosis neuronal protein 3 (CLN3), but its cell function has not ...
Jaime Cárcel-Trullols
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