Results 81 to 90 of about 108,576 (328)
Advanced Healthcare Materials, EarlyView.A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues +6 more
wiley +1 more source
Cysteine Cathepsins and Matrix Metalloproteases Among Breast Cancer Patients
Breast Cancer: Targets and Therapy, 2021 Solomon Tsegaye,1 Mohammed Mehdi,2 Wajana L Labisso,3 Daniel Seifu Melka2 1Department of Biochemistry, College of Health Sciences, Assela University, Addis Ababa, Ethiopia; 2Department of Biochemistry, College of Health Sciences, Addis Ababa University ...
Tsegaye S, Mehdi M, Lako WL, Melka DS
doaj
Lysosomal proteases are involved in generation of N-terminal huntingtin fragments
Neurobiology of Disease, 2006 N-terminal mutant huntingtin (N-mhtt) fragments form inclusions and cause cell death in vitro. Mutant htt expression stimulates autophagy and increases levels of lysosomal proteases. Here, we show that lysosomal proteases, cathepsins D, B and L, affected
Yun J. Kim +9 more
doaj +1 more source
T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes [PDF]
, 2013 Aims: African trypanosomiasis, caused by Trypanosoma brucei species, leads to both neurological and cardiac dysfunction and can be fatal if untreated. While the neurological-related pathogenesis is well studied, the cardiac pathogenesis remains unknown ...
Abdulla +36 more
core +2 more sources
Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy
Advanced Materials, EarlyView.Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa +3 more
wiley +1 more source
CyTA - Journal of Food, 2019 In order to evaluate the relationship between of endogenous enzymes and physiochemical indicators during the processing of dry-salted Decapterus maruadsi produced by the traditional method.
Yan Yan Wu +6 more
doaj +1 more source
Rab14 regulates the maturation of macrophage phagosomes containing the fungal pathogen Candida albicans and the outcome of the host-pathogen interaction [PDF]
, 2015 Date of Acceptance: 02/02/2015 Copyright © 2015, American Society for Microbiology.
Bain, Judith M +4 more
core +2 more sources
Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration
Advanced Materials Technologies, EarlyView.This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley +1 more source
Autophagy is activated and involved in cell death with participation of cathepsins during stress-induced microspore embryogenesis in barley [PDF]
, 2018 Microspores are reprogrammed towards embryogenesis by stress. Many microspores die after this stress, limiting the efficiency of microspore embryogenesis. Autophagy is a degradation pathway that plays critical roles in stress response and cell death.
Berenguer, Eduardo +4 more
core +1 more source
Advanced Science, EarlyView.CCDC41 is essential for meiotic maturation in mouse oocytes through regulating Rab7‐positive endosomes fusion with lysosomes and Rab11a‐positive vesicle fusion with the plasma membrane. Abstract Coiled‐coil domain‐containing protein 41 (CCDC41), a core component of centriolar distal appendages involved in centriole assembly and ciliary vesicle docking,
Ying Tian +12 more
wiley +1 more source