Results 111 to 120 of about 51,705 (353)

Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene (DMBA)‐induced leukemia rat model: Parallels with human leukemogenesis

Animal Models and Experimental Medicine, EarlyView.
7,12‐Dimethylbenz[a]anthracene (DMBA) could induce leukemia and other types of cancers in rat models. Transcriptomics revealed gene expression profile that parallels with human leukemia. DMBA‐induced differential gene expression could validate the developed rat model.
Khaldoon Alsamman, Omar S. El‐Masry
wiley   +1 more source

Unveiling the Roles of Cysteine Proteinases F and W: From Structure to Pathological Implications and Therapeutic Targets

Cells
Cysteine cathepsins F and W are members of the papain-like cysteine protease family, which have distinct structural features and functional roles in various physiological and pathological processes.
Kristina Zdravkova, Olja Mijanovic, Ana Brankovic, Polina M. Ilicheva, Aleksandra Jakovleva, Jelena Karanovic, Milena Pualic, Dusan Pualic, Aleksandr A. Rubel, Lyudmila V. Savvateeva, Alessandro Parodi, Andrey A. Zamyatnin   +11 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Cathepsin X-deficient Gastric Epithelial Cells in Co-culture with Macrophages [PDF]

, 2010
Anja Bernhardt, Doerthe Kuester, Albert Roessner, Thomas Reinheckel, Sabine Krueger   +4 more
openalex   +1 more source

Repurposing of 8‐Hydroxyquinoline‐Based Butyrylcholinesterase and Cathepsin B Ligands as Potent Nonpeptidic Deoxyribonuclease I Inhibitors

, 2022
Mihajlo Gajić, Damijan Knez, Izidor Sosič, Janez Mravljak, A. Meden, Urban Košak, Luisa Leitzbach, Sven George, Bettina Hofmann, Aleksandra Živković, Dieter Steinhilber, Holger Stark, Stanislav Gobec, Andrija Šmelcerović, Marko Anderluh   +14 more
openalex   +2 more sources

Human Melanoma and Glioblastoma Cells Express Cathepsins Supporting Reovirus Moscow Strain Infection

Viruses
This study evaluates the oncolytic potential of the Moscow strain of reovirus against human metastatic melanoma and glioblastoma cells. The Moscow strain effectively infects and replicates within human melanoma cell lines and primary glioblastoma cells ...
Yulia Ammour, Eugenia Nikolaeva, Olesya Sagimbaeva, Pavel Shamsutdinov, Anastasia Astapenko, Yulia Zhelaeva, Marina Gavrilova, Olga Susova, Aleksey Mitrofanov, Ali Bekyashev, Tatiana Nasedkina, Oxana Svitich, Evgeny Faizuloev, Vitaly Zverev   +13 more
doaj   +1 more source

Cathepsin-Activatable Cy5 Fluorescent Imaging Probe LUM015 [PDF]

, 2020
National Cancer Institute
openalex   +1 more source

Spotlight on Proteases: Roles in Ovarian Health and Disease

Cells
Proteases play crucial roles in ovarian folliculogenesis, regulating several processes from primordial follicle activation to ovulation and corpus luteum formation.
Bhawna Kushawaha, Emanuele Pelosi
doaj   +1 more source

The purification and properties of a proteolytic enzyme, rabbit cathepsin E, and further studies on rabbit cathepsin D [PDF]

, 1962
C Lapresle, Tom R. Webb
openalex   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source