Results 91 to 100 of about 51,705 (353)
Regulation of apoptosis-associated lysosomal membrane permeabilization [PDF]
, 2010 Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimuli causing release of cathepsins from the lysosomal lumen into the cytosol where they participate in apoptosis signaling.
Ann-Charlotte Johansson +5 more
core +2 more sources
Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES
Advanced Science, EarlyView.In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu +5 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2012 The activity of cysteine peptidases (cathepsins B and L) was estimated in homogenates of tissues sampled during surgery from 60 patients operated due to colorectal tumors.
Julia Rudno-Rudzinska +7 more
doaj +1 more source
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. [PDF]
, 2013 BACKGROUND: Lysosomes play important roles in multiple aspects of physiology, but the problem of how the transcription of lysosomal genes is coordinated remains incompletely understood.
Bartlett, NW +9 more
core +2 more sources
Advanced Science, EarlyView.This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang +9 more
wiley +1 more source
Cysteine cathepsins control hepatic NF-κB-dependent inflammation via sirtuin-1 regulation [PDF]
, 2016 Sirtuin-1 (SIRT1) regulates hepatic metabolism but its contribution to NF-κB-dependent inflammation has been overlooked. Cysteine cathepsins (Cathepsin B or S, CTSB/S) execute specific functions in physiological processes, such as protein degradation ...
Colell Riera, Anna +8 more
core +1 more source
Advanced Science, EarlyView.An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou +9 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, EarlyView.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Post-mortem degradation of myosin heavy chain in intact fish muscle: Effects of pH and enzyme inhibitors [PDF]
, 2001 Fish muscle is rapidly degraded during post-mortem storage, due to proteolytic enzymes acting probably both on muscle cells and connective tissue.
Wang, P. A. +4 more
core +1 more source
Advanced Science, EarlyView.A fibroblast activation protein (FAP)‐targeted small molecule–drug conjugate (SMDC) platform is developed to integrate PET imaging with synergistic radionuclide–chemotherapy. Linker chemistry governs stability, exposure, and tolerability, with the VC linker providing superior in vivo performance.
Ruitao Yang +6 more
wiley +1 more source