Results 141 to 150 of about 20,637 (212)

Coordinated regional association of cathepsins and dipeptidyl peptidases with N-truncated Abeta42, Abeta40, and tau in Alzheimer's brain. [PDF]

Acta Neuropathol Commun
Shinohara M, Gheni G, Kawai K, Morishima M, Murayama S, Saito Y, Bu G, Sato N.   +7 more
europepmc   +1 more source

Clinically relevant intra‐articular corticosteroid doses impair equine osteoclast function in vitro

Veterinary Surgery, EarlyView.
Abstract Objective To assess the effects of clinically relevant doses of commonly employed intra‐articular corticosteroids—specifically, triamcinolone acetonide (TCA), methylprednisolone acetate (MPA), and combination of betamethasone acetate and betamethasone sodium phosphate (BM)—on equine osteoclasts.
Gwladys Malek, Louis Kamus, Hélène Richard, Guy Beauchamp, Sheila Laverty   +4 more
wiley   +1 more source

Effects of Deheading and Intestinal Removal on Protein Degradation and Quality Changes in Chilled <i>Litopenaeus vannamei</i>. [PDF]

Foods
Jia S, Zhao Y, Zhuang S, Zeng H, Chang J, Liu S, Ding Y, Zhou X, Wang Y.   +8 more
europepmc   +1 more source

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Chemiluminescent probes for imaging cysteine cathepsin activity. [PDF]

Bioorg Med Chem Lett
Zhu J, Gutkin S, Chen S, Su SP, Phan H, Shabat D, Bogyo M.   +6 more
europepmc   +1 more source

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise

Experimental Physiology, EarlyView.
Abstract Cancer cachexia (CC) is a multifactorial disease marked by a severe and progressive loss of lean muscle mass and characterized further by inflammation and a negative energy/protein balance, ultimately leading to muscle atrophy and loss of muscle tissue.
Zoe P. Libramento, Louisa Tichy, Traci L. Parry   +2 more
wiley   +1 more source

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study. [PDF]

Discov Oncol
Guo B, Zhou Z, Liao W, Zheng Y, Liao Y, Zeng R.   +5 more
europepmc   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages. [PDF]

Mol Pharm
Musil D, Krhutová M, Blažková K, Kramná A, Brázdová A, Výmolová B, Houdová Megová M, Hadzima M, Kryštůfek R, Šubr V, Kostka L, Etrych T, Ormsby T, Šácha P, Abramson J, Konvalinka J.   +15 more
europepmc   +1 more source

Ageing alters cysteine oxidation‐regulated redox signalling in skeletal muscle: Integrative omics and AI‐based structural predictions

Experimental Physiology, EarlyView.
Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley   +1 more source