Results 141 to 150 of about 51,705 (353)

65. Cathepsin B-Labile Polymers for Endosome/Lysosome-Specific Degradation and Nucleic Acid Release [PDF]

, 2011

openalex   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Cathepsin Proteases in Toxoplasma gondii

, 2011
Zhicheng Dou, Vern B. Carruthers
openalex   +2 more sources

Proteinases [PDF]

, 1993
Fritz, Hans, Jochum, Marianne, Machleidt, W., Neuhof, H., Redl, H., Schlag, Günther   +5 more
core   +1 more source

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease. [PDF]

, 2019
Proteinaceous aggregation is a well-known observable in Alzheimer's disease (AD), but failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually precedes bulk accumulation of extracellular amyloid plaque. In fact, AD shares
Augello, Catherine, Coburn, Emily, Ford, Byron D, Julian, Ryan R, Kang, Amrik S, Lambeth, Tyler R, Noll, Jessica, Riggs, Dylan L, Talbert, Lance E, Tang, Jin   +9 more
core   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte–endothelial cell signaling and JNK activation

, 2012
Philip M. Keegan, Catera L. Wilder, Manu O. Platt   +2 more
openalex   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Deficiency of the Cysteine Protease Cathepsin S Impairs Microvessel Growth [PDF]

, 2003
Guo‐Ping Shi, Galina K. Sukhova, Masafumi Kuzuya, Q. Ye, Jie Du, Y. Zhang, Jiehong Pan, Michael L. Lu, Xian Wu Cheng, Akihisa Iguchi, Stéphane Perrey, A.M.-E. Lee, Harold A. Chapman, Peter Libby   +13 more
openalex   +1 more source

Proteolysis of defensive proteins in peritonitis exudate [PDF]

, 1991
Assfalg-Machleidt, Irmgard, Billing, A., Fröhlich, D., Jochum, Marianne, Machleidt, W.   +4 more
core   +1 more source