β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury. [PDF]
Zhen W +5 more
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Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson +6 more
wiley +1 more source
CCL20 mediates the effect of cathepsin S on hepatocellular carcinoma development insights from Mendelian randomization and bioinformatics analysis. [PDF]
Yuan C +8 more
europepmc +1 more source
Deciphering the regulatory mechanism and therapeutic potential of ECM degradation in intervertebral disc degeneration via multi-omics integration. [PDF]
Feng L, Zhong W, Liu W, Guo X, Wu L.
europepmc +1 more source
Genetic and molecular evidence linking CTSH to Alzheimer's disease pathophysiology. [PDF]
Picard C +7 more
europepmc +1 more source
Genetic Evidence for Causal Relationships Between Circulating Cathepsin Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study. [PDF]
Duan C, Zhang A, Tian S.
europepmc +1 more source
Genetic evidence for CTSH as a potential therapeutic target in sepsis: A Mendelian randomization and colocalization study. [PDF]
Du Y +5 more
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RETRACTION: Association Between Cathepsins and Skin Cancers: A Bidirectional Two-Sample Mendelian Randomization Study. [PDF]
europepmc +1 more source
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The mechanism by which bone collagen and other organic components are degraded by the osteoclast during osteoclastic bone resorption was unclear until the 1980s. Studies conducted since the early 1990s have identified lysosomal proteases, mainly cathepsins that are active at low pH, involved in osteoclastic bone resorption.
Tetsuya, Goto +2 more
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Cathepsin B is a lysosomal cysteine protease of the papain family. It functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover.
J S, Mort, D J, Buttle
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