Results 161 to 170 of about 20,584 (256)

Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface

Plant Biotechnology Journal, EarlyView.
ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng, Shuqin Zheng, Federica Brandizzi, Yiran Liu, Chunlei Li, Congcong Ai, Yujiao Wang, Jiadong Qi, Xiuguo Zhang   +8 more
wiley   +1 more source

CD64-Targeted Polymer-Drug Conjugates Exploit Cathepsin K-Dependent Payload Release for Selective Elimination of Immunosuppressive Macrophages. [PDF]

Mol Pharm
Musil D, Krhutová M, Blažková K, Kramná A, Brázdová A, Výmolová B, Houdová Megová M, Hadzima M, Kryštůfek R, Šubr V, Kostka L, Etrych T, Ormsby T, Šácha P, Abramson J, Konvalinka J.   +15 more
europepmc   +1 more source

Effects of Deheading and Intestinal Removal on Protein Degradation and Quality Changes in Chilled <i>Litopenaeus vannamei</i>. [PDF]

Foods
Jia S, Zhao Y, Zhuang S, Zeng H, Chang J, Liu S, Ding Y, Zhou X, Wang Y.   +8 more
europepmc   +1 more source

Deciphering the regulatory mechanism and therapeutic potential of ECM degradation in intervertebral disc degeneration via multi-omics integration. [PDF]

Front Immunol
Feng L, Zhong W, Liu W, Guo X, Wu L.
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Deciphering the role of cathepsins in digestive system cancers: a Mendelian randomization study. [PDF]

Discov Oncol
Guo B, Zhou Z, Liao W, Zheng Y, Liao Y, Zeng R.   +5 more
europepmc   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

β-amyloid and β-amyloid precursor protein synthesis and processing: effects of exercise and exercise-related injury. [PDF]

Front Cell Neurosci
Zhen W, Xing Y, Li Y, Hao J, Kong L, Zhen H.   +5 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source