Results 191 to 200 of about 84,247 (372)

Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone

Cancer Science, EarlyView.
The roles of nonimmune systems in tumor regulation remain largely undefined. This article introduces a new concept, “stromal defense against cancer (SDAC),” which is based on recent findings that the periosteum actively responds to tumor proximity and physically impedes tumor invasion into bone.
Masayuki Tsukasaki, Hiroshi Takayanagi
wiley   +1 more source

Prosaposin Is Cleaved Into Saposins by Multiple Cathepsins in a Progranulin-Regulated Fashion. [PDF]

J Neurochem
Hodul M, Lane-Donovan C, Cheang ES, Gao V, Sampognaro PJ, Mambou EA, Yang Z, Kao AW.   +7 more
europepmc   +1 more source

Nicotine Affects Bone Resorption and Suppresses the Expression of Cathepsin K, MMP-9 and Vacuolar-Type H+-ATPase d2 and Actin Organization in Osteoclasts

, 2013
Hideki Tanaka, Natsuko Tanabe, Takayuki Kawato, Kumiko Nakai, Taro Kariya, Sakurako Matsumoto, Ning Zhao, Masafumi Motohashi, Masao Maeno   +8 more
openalex   +2 more sources

Frontline Science: Multiple cathepsins promote inflammasome‐independent, particle‐induced cell death during NLRP3‐dependent IL‐1β activation

Journal of Leukocyte Biology, 2017
Gregory Orlowski, Shruti Sharma, Jeff D. Colbert, M. Bogyo, S. Robertson, H. Kataoka, F. K. Chan, K. Rock   +7 more
semanticscholar   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Microglial Cathepsin B Contributes to the Initiation of Peripheral Inflammation-Induced Chronic Pain [PDF]

, 2012
Li Sun, Zhou Wu, Yoshinori Hayashi, Christoph Peters, Makoto Tsuda, Kazuhide Inoue, Hiroshi Nakanishi   +6 more
openalex   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source

It's a Trap!-Potential of Cathepsins in NET Formation. [PDF]

Int J Mol Sci
Pruchniak P, Niedzielska A, Nejfeld R, Wyżewski Z, Gregorczyk-Zboroch KP, Szulc-Dąbrowska L, Gieryńska M.   +6 more
europepmc   +1 more source

Cathepsin B Gene Disruption Induced Leishmania donovani Proteome Remodeling Implies Cathepsin B Role in Secretome Regulation

, 2013
Teklu K. Gerbaba, Lashitew Gedamu
openalex   +2 more sources

Identification of a Novel Mutation in the Cathepsin K (CTSK) Gene in Iranian Patients with Pycnodysostosis

, 2022
Abdolazim Sarli, Sarina Sharbatkhori, Ali Kowsari   +2 more
openalex   +2 more sources