Results 241 to 250 of about 84,247 (372)

Expression of a constitutively active nitrate reductase increases SARS‐CoV‐2 Spike protein production in Nicotiana benthamiana leaves that otherwise show traits of senescence

Plant Biotechnology Journal, EarlyView.
Summary The production of coronavirus disease 2019 vaccines can be achieved by transient expression of the Spike (S) protein of Severe Acute Respiratory Syndrome Coronavirus 2 in agroinfiltrated leaves of Nicotiana benthamiana, a process promoted by the co‐expression of viral silencing suppressor P19.
Louis‐Philippe Hamel, Marie‐Ève Paré, Francis Poirier‐Gravel, Rachel Tardif, Marc‐André Comeau, Pierre‐Olivier Lavoie, Andréane Langlois, Marie‐Claire Goulet, Marc‐André D'Aoust, Dominique Michaud   +9 more
wiley   +1 more source

Genomes of Fasciola hepatica from the Americas reveal colonization with Neorickettsia endobacteria related to the agents of Potomac horse and human Sennetsu fevers [PDF]

, 2017
Choi, Young-Jun, et al.,, Fischer, Peter U, Hallsworth-Pepin, Kymberlie, McNulty, Samantha N, Mitreva, Makedonka, Rosa, Bruce A, Tyagi, Rahul   +7 more
core   +1 more source

Novel treatment strategies for cardiovascular and pulmonary diseases: Insights from cathepsin-related Mendelian randomization and Bayesian colocalization. [PDF]

Medicine (Baltimore)
Zhang C, Xu B, Yu T, He F, Hang F, Qian W.   +5 more
europepmc   +1 more source

Design of Hybrid Bioactive Peptides Derived From Cecropin and Cathepsin for Therapeutic Application. [PDF]

Chem Biol Drug Des
Cepinho GS, Scavassa BV, de Cena GL, de Andrade VM, Lima LRF, Zelanis A, Heras M, Castanho MARB, Conceição K.   +8 more
europepmc   +1 more source

The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage

Journal of Neuroscience, 2015
J. Ni, Zhou Wu, Christoph Peterts, Kenji Yamamoto, H. Qing, H. Nakanishi   +5 more
semanticscholar   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction

, 2020
Angélique Chevriaux, Thomas Pilot, Valentin Dérangère, Harmonie Simonin, Pierre Martine, Fanny Chalmin, François Ghiringhelli, Cédric Rébé   +7 more
openalex   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Targeting Glycolysis with 2-Deoxy-D-Glucose and Lysosomal Integrity with L-Leucyl-L-Leucine Methyl Ester as Antimelanoma Strategy. [PDF]

Pharmaceutics
Kosic M, Bosnjak M, Mandic M, Vucicevic L, Marjanovic MM, Poulsen SE, Harhaji-Trajkovic L.   +6 more
europepmc   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source