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Cathinone derivatives: A review of their chemistry, pharmacology and toxicology
Drug Testing and Analysis, 2011 The purpose of this review is to evaluate what is currently known about the pharmacology of cathinone derivatives. Cathinone is the principal active constituent of khat responsible for the stimulant effects that have led khat to be known as a ‘natural ...
John P Kelly
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Synthetic cathinones and cardiotoxicity risks.
La Clinica terapeutica, 2022Recently, there has been a worldwide rise in the popularity and abuse of synthetic cathinones. The spectrum of side effects caused by the intake of these drugs of abuse is very wide since they act on different systems with various mechanisms of action, they appear to be involved in different cardiac events, including myocardial infarction and sudden ...
Lo Faro, A., Berretta, P., Montana , A.
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European Neuropsychopharmacology, 2013 The synthetic cathinone derivative, mephedrone, is a controlled substance across Europe. Its effects have been compared by users to 3,4-methylenedioxymethamphetamine (MDMA), but little data exist on its pharmacological properties. This study compared the
Kevin Fone +2 more
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An updated review on synthetic cathinones
Archives of Toxicology, 2021Cathinone, the main psychoactive compound found in the plant Catha edulis Forsk. (khat), is a β-keto analogue of amphetamine, sharing not only the phenethylamine structure, but also the amphetamine-like stimulant effects. Synthetic cathinones are derivatives of the naturally occurring cathinone that largely entered the recreational drug market at the ...
Jorge Soares +4 more
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Illicit cathinone (“Hagigat”) poisoning
Clinical Toxicology, 2008Khat leaves (mainly cathinone and cathine) have been chewed for centuries as stimulants. Hagigat (capsules of 200 mg cathinone) have been marketed in Israel as a natural stimulant and aphrodisiac. The consequences of illicit exposure to cathinone are reported.Prospective observational study of calls to the Poison Center regarding exposure to Hagigat ...
Yedidia Bentur
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Mephedrone and other cathinones
Current Opinion in Psychiatry, 2014New designer drugs are constantly emerging in the illicit drug market and represent a significant health problem. A very popular class comprises synthetic cathinones, β-keto amphetamine analogues, endowed with psychostimulant properties. The aim of this review is to discuss the recent progress in our understanding of how cathinones act and the health ...
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Cathinone, a Natural Amphetamine
Pharmacology & Toxicology, 1992Abstract:Cathinone is an alkaloid that has been discovered some fifteen years ago in the leaves of the khat bush. This plant grows in East Africa and in southern Arabia, and the inhabitants of these regions frequently chew khat because of its stimulating properties. Cathinone, which is S(–)‐α‐aminopropiophenone, was soon found to have a pharmacological
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Discriminative properties of l-cathinone compared to dl- and d-cathinone
Pharmacology Biochemistry and Behavior, 1986Rats were trained to discriminate between the stimulus properties of 0.6 mg/kg l-cathinone and its vehicle in a two-lever, food-motivated operant task. Once trained, rats showed a dose-dependent decrease in discrimination performance with lower l-cathinone doses and analysis of the dose-response relationship indicated an ED50 of 0.19 mg/kg ...
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Khat and synthetic cathinones: a review
Archives of Toxicology, 2013For centuries, 'khat sessions' have played a key role in the social and cultural traditions among several communities around Saudi Arabia and most East African countries. The identification of cathinone as the main psychoactive compound of khat leaves, exhibiting amphetamine-like pharmacological properties, resulted in the synthesis of several ...
Valente, Maria João +4 more
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Blood concentrations of synthetic cathinones
Clinical Toxicology, 2020Synthetic cathinones are the second most frequently seized group of new psychoactive substances. They are sold as replacements for controlled stimulants such as amphetamine, cocaine and MDMA. Synthetic cathinones are often determined in biological material collected from both living people and fatally intoxicated with these substances.
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