Results 91 to 100 of about 17,019 (205)

The cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II.

Journal of Biological Chemistry, 1988
The bovine cation-independent mannose 6-phosphate receptor (CI-MPR) and the human insulin-like growth factor II (IGF-II) receptor have recently been shown to be 80% identical in their amino acid sequences as deduced from cDNA clones (Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., and Rutter, W. J.
P Y, Tong, S E, Tollefsen, S, Kornfeld
openaire   +2 more sources

Alterations in EGF-Endocytosis, Lysosomal Enzyme Transport and Maturation of Cathepsins in Juvenile Neuronal Ceroid Lipofuscinosis Fibroblasts

International Clinical Neuroscience Journal, 2020
Background: Juvenile neuronal ceroid lipofuscinosis (JNCL), one of the most frequent forms of the NCL storage diseases, is known to be caused by loss-of-function mutations in ceroid-lipofuscinosis neuronal protein 3 (CLN3), but its cell function has not ...
Jaime Cárcel-Trullols
doaj   +1 more source

Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies [PDF]

, 2000
SUMMARYA number of recent studies have highlighted the importance of lipid domains within endocytic organelles in the sorting and movement of integral membrane proteins.
Paula Row
core  

Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors [PDF]

, 2001
ACE inhibitors improve endothelial dysfunction, possibly by blocking endothelial angiotensin production. Prorenin, through its binding and activation by endothelial mannose 6-phosphate (M6P) receptors, may contribute to ...
Bruin, R.J.A. (René) de, Danser, A.H.J. (Jan), Derkx, F.H.M. (Frans), Eijnden, M.M.E.D. (Mark) van den, Reudelhuber, T.L., Saris, J.J. (Jasper), Schalekamp, M.A.D.H. (Maarten), Sluiter, W. (Wim), Wit, E. (Emmie) de   +8 more
core   +2 more sources

Domain-substituted IGF2 tag modulates targeting of lentiviral gene therapy for Hunter syndrome

EMBO Molecular Medicine
We present the SWAP design, a novel, structurally cohesive IGF2-based tag for modular receptor targeting during gene therapy for lysosomal storage disorders (LSDs).
Fabio Catalano, Dejan Stevic, Giacomo Zundo, Tessa F Huizer, Zina Dammou, Eva C Vlaar, Drosos Katsavelis, Jeroen C van den Bosch, Hannerieke J M P van den Hout, Esmeralda Oussoren, Ans T van der Ploeg, George J G Ruijter, Gerben Schaaf, W W M Pim Pijnappel   +13 more
doaj   +1 more source

Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments

Journal of Lipid Research, 2003
It has been reported that an accumulation of cholesterol within late endosomes/lysosomes in Niemann-Pick type C (NPC) fibroblasts and U18666A-treated cells causes impairment of retrograde trafficking of the cation-independent mannose 6-phosphate/IGF-II ...
Atsushi Umeda, Hideaki Fujita, Toshio Kuronita, Kaori Hirosako, Masaru Himeno, Yoshitaka Tanaka   +5 more
doaj   +1 more source

Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation [PDF]

, 2001
Lipid kinases and their phosphorylated products are important regulators of many cellular processes, including intracellular membrane traffic. The best example of this is provided by the class III phosphoinositide 3-kinase (PI-3K), Vps34p, which is ...
Paula Row
core   +1 more source

Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos [PDF]

, 1992
We present evidence that insulin-like growth factor II (IGF-II) mediates growth in early mouse embryos and forms a pathway in which imprinted genes influence development during preimplantation stages, mRNA and protein for IGF-II were expressed in ...
Behrendtsen, Ole, Pedersen, Roger A., Rappolee, Daniel A., Schultz, Gilbert A., Sturm, Karin S., Werb, Zena   +5 more
core   +2 more sources

Glycan microarrays : new angles and new strategies [PDF]

, 2014
Carbohydrate microarrays, comprising hundreds to thousands of different glycan structures on solid surfaces in a spatially discrete pattern, are sensitive and versatile tools for the analysis of glycosylation changes in complex biological samples ...
Donczo, Boglarka, Guttman, András, Kerékgyártó, János, Szurmai, Zoltán   +3 more
core   +1 more source

Prorenin and the heart : the Mannose 6-phosphate connection [PDF]

, 2002
The knowledge concerning the formation of angiotensins at cardiac tissue sites in relation to the presence and origin of cardiac renin, angiotensinogen and ACE is evaluated in chapter 2.
Saris, J.J. (Jasper)
core   +5 more sources