Results 101 to 110 of about 17,019 (205)

Leucine zipper transcription factor-like 1 binds adaptor protein complex-1 and 2 and participates in trafficking of transferrin receptor 1.

PLoS ONE, 2020
LZTFL1 participates in immune synapse formation, ciliogenesis, and the localization of ciliary proteins, and knockout of LZTFL1 induces abnormal distribution of heterotetrameric adaptor protein complex-1 (AP-1) in the Lztfl1-knockout mouse photoreceptor ...
Kanyarat Promchan, Ven Natarajan
doaj   +1 more source

Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins

Frontiers in Immunology
Inducing the degradation of pathological soluble antigens could be the key to greatly enhancing the efficacy of therapeutic monoclonal antibodies (mAbs), extensively used in the treatment of autoimmune and inflammatory disorders or cancer.
Morgane Daurat, Corentin Gauthier, Corentin Gauthier, Khaled El Cheikh, Lamiaa M. A. Ali, Lamiaa M. A. Ali, Elodie Morère, Elodie Morère, Nadir Bettache, Magali Gary-Bobo, Alain Morère, Marcel Garcia, Marie Maynadier, Ilaria Basile   +13 more
doaj   +1 more source

Impact of chemical modification of sulfamidase on distribution to brain interstitial fluid and to CSF after an intravenous administration in awake, freely-moving rats

Molecular Genetics and Metabolism Reports, 2020
Mucopolysaccharidosis III A (MPS IIIA) is an autosomal recessive lysosomal storage disorder caused by deficiency of the enzyme sulfamidase. The disorder results in accumulation of heparan sulfate, lysosomal enlargement and cellular and organ dysfunction.
Juliette Janson, Gudrun Andersson, Lars Bergquist, Maria Eriksson, Joost H.A. Folgering   +4 more
doaj   +1 more source

Emerging Roles of the Intraflagellar Transport System in the Orchestration of Cellular Degradation Pathways

Frontiers in Cell and Developmental Biology, 2019
Ciliated cells exploit a specific transport system, the intraflagellar transport (IFT) system, to ensure the traffic of molecules from the cell body to the cilium.
Francesca Finetti, Nagaja Capitani, Cosima T. Baldari   +2 more
doaj   +1 more source

High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin [PDF]

, 2001
Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II (man-6-P/IgF-II) receptors are involved in the activation of recombinant human prorenin by cardiomyocytes.
Bruin, R.J.A. (René) de, Danser, A.H.J. (Jan), Dekkers, D.H. (Dick), Derkx, F.H.M. (Frans), Lamers, J.M.J. (Jos), Saris, J.J. (Jasper), Saxena, P.R. (Pramod Ranjan), Schalekamp, M.A.D.H. (Maarten)   +7 more
core  

Molecular Mechanisms Used by Salmonella to Evade the Immune System [PDF]

, 2017
Human and animal pathogens are able to circumvent, at least temporarily, the sophisticated immune defenses of their hosts. Several serovars of the Gram-negative bacterium Salmonella enterica have been used as models for the study of pathogen-host ...
Bernal Bayard, Joaquín, Ramos Morales, Francisco   +1 more
core   +1 more source

Association of p60c-src with endosomal membranes in mammalian fibroblasts. [PDF]

, 1992
We have examined the subcellular localization of p60c-src in mammalian fibroblasts. Analysis of indirect immunofluorescence by three-dimensional optical sectioning microscopy revealed a granular cytoplasmic staining that co-localized with the microtubule
Kaplan, KB, Morgan, DO, Swedlow, JR, Varmus, HE   +3 more
core   +1 more source

Molecular regulation of GLUT-4 targeting in 3T3-L1 adipocytes [PDF]

, 1995
Insulin stimulates glucose transport in muscle and adipose tissue by triggering the movement of the glucose transporter GLUT-4 from an intracellular compartment to the cell surface. Fundamental to this process is the intracellular sequestration of GLUT-4
Alm, R. A., James, D. E., Marsh, B. J., McIntosh, S. R.   +3 more
core   +1 more source

Functional dissection of COP-I subunits in the biogenesis of multivesicular endosomes [PDF]

, 1997
In the present paper, we show that transport from early to late endosomes is inhibited at the restrictive temperature in a mutant CHO cell line (ldlF) with a ts-defect in epsilon coatomer protein (epsilon COP), although internalization and recycling ...
Aniento, Aniento, Besterman, Bomsel, Bradford, Brown, Chavrier, Clague, Cosson, Diment, Dunn, Fiedler, Futter, Geuze, Gorvel, Griffiths, Gruenberg, Gruenberg, Gruenberg, Gruenberg, Guo, Guo, Harder, Hobbie, Kornfeld, Koval, Kreis, Kreis, Letourneur, Lowe, Ludwig, Mellman, Mellman, Mu, Orci, Ostermann, Pagano, Parton, Parton, Pearse, Pelham, Pepperkok, Robinson, Rojo, Sipe, Sohn, Tooze, Trowbridge, van Deurs, Wada, Whitney, Yamashiro, Zerial   +52 more
core   +3 more sources

An amphitropic cAMP-binding protein in yeast mitochondria [PDF]

, 1989
: We describe the first example of a mitochondrial protein with a covalently attached phos-phatidylinositol moiety acting as a membrane anchor. The protein can be metabolically labeled with both stearic acid and inositol.
Bandlow W., Baranska J., Blok M., Brugge J., Burn P., Burn P., Cascales S. C., Cobon G. S., Cobon G. S., Cornell R., Courtneidge S. A., Cross G. A. M., Dils R. R., Dygas A., Gillfillan A. M., Guarnieri M., Hixson C. S., Hostetler K. Y., Jelsema C. L., Kraft A. S., Lassing I., Lassing I., Low M. G., Megli F. M., Meyer R. K., Muller G., Muller G., Muller G., Muller G., Nishizuka Y., Pelech S. L., Radika R., Rodel G., Rotman A., Schmidt M. F. G., Sefton B. M., Sleight R., Terce F., Towbin H., Wirtz K. W. A., Wirtz K. W. A., Wojtczak L., Yaffe M., Zborowski J.   +43 more
core   +3 more sources