Results 111 to 120 of about 17,019 (205)

Targeted protein degradation through site-specific antibody conjugation with mannose 6-phosphate glycan

mAbs
Recent developments in targeted protein degradation have provided great opportunities to eliminating extracellular protein targets using potential therapies with unique mechanisms of action and pharmacology.
Kaori Mukai, Robert Cost, Xin Sheen Zhang, Emily Condiff, Joanne Cotton, Xiaohua Liu, Ekaterina Boudanova, Björn Niebel, Peter Piepenhagen, Xinming Cai, Anna Park, Qun Zhou   +11 more
doaj   +1 more source

Evidence of mature adipocyte proliferation regulated by proliferin [PDF]

, 2010
Despite much research, whether mature adipocytes proliferate remains controversial. Here, we examined 5-bromo-2′-deoxyuridine (BrdU)-labelling of mature adipocytes.
Aki Minami, Hideyuki Okada, Hiroyuki Morita, Ichiro Mori, Isao Nagano, Kazuo Kajita, Kei Fujioka, Masahiro Yamauchi, Masao Takemura, Mitsuru Seishima, Takahide Ikeda, Takayuki Hanamoto, Tatsuo Ishizuka, Toshiko Kajita, Wu Zhiliang, Yoshihiro Uno, Yuzo Takahashi   +16 more
core   +1 more source

Cipaglucosidase alfa plus miglustat: linking mechanism of action to clinical outcomes in late-onset Pompe disease

Frontiers in Neurology
Enzyme replacement therapy (ERT) is the only approved disease-modifying treatment modality for Pompe disease, a rare, inherited metabolic disorder caused by a deficiency in the acid α-glucosidase (GAA) enzyme that catabolizes lysosomal glycogen.
Barry J. Byrne, Giancarlo Parenti, Giancarlo Parenti, Benedikt Schoser, Ans T. van der Ploeg, Hung Do, Brian Fox, Mitchell Goldman, Franklin K. Johnson, Jia Kang, Nickita Mehta, John Mondick, M. Osman Sheikh, Sheela Sitaraman Das, Steven Tuske, Jon Brudvig, Jill M. Weimer, Tahseen Mozaffar   +17 more
doaj   +1 more source

Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway. [PDF]

, 1988
Roland Baron, Lynn Neff, W. E. Brown, Pierre J. Courtoy, Daniel Louvard, M G Farquhar   +5 more
openalex   +1 more source

The chicken liver cation-independent mannose 6-phosphate receptor lacks the high affinity binding site for insulin-like growth factor II

, 1989
William M. Canfield, Stuart Kornfeld
openalex   +1 more source

IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B

Cell Death and Disease
Cytotoxic T lymphocytes (CTL) exploit specialized secretory lysosomes, the lytic granules (LG) to kill target cells. The LGs carry a battery of apoptosis-inducing molecules enriched in granzymes (GZM), perforin and FasL, which are released at the immune ...
Francesca Finetti, Fabrizia Zevolini, Loredana Migliore, Valentina Cianfanelli, Leandro Marzuoli, Nagaja Capitani, Chiara Cassioli, Laura Patrussi, Cristina Ulivieri, Giuseppe Marotta, Cosima T. Baldari   +10 more
doaj   +1 more source

Mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor. A consensus casein kinase II site followed by 2 leucines near the carboxyl terminus is important for intracellular targeting of lysosomal enzymes.

, 1993
H.J. Chen, Johannes Remmler, James C. Delaney, Donald J. Messner, Peter Lobel   +4 more
openalex   +1 more source

Low density lipoprotein receptor and cation-independent mannose 6-phosphate receptor are transported from the cell surface to the Golgi apparatus at equal rates in PC12 cells [PDF]

, 1992
SA Green, R B Kelly
openalex   +1 more source

Role for Dynamin in Late Endosome Dynamics and Trafficking of the Cation-independent Mannose 6-Phosphate Receptor

, 2000
Paolo Nicoziani, Frederik Vilhardt, Alicia Llorente, Leila Hilout, Pierre J. Courtoy, Kirsten Sandvig, Bo van Deurs   +6 more
openalex   +2 more sources

Phosphorylation of the cytoplasmic domain of the bovine cation-independent mannose 6-phosphate receptor. Serines 2421 and 2492 are the targets of a casein kinase II associated to the Golgi-derived HAI adaptor complex.

, 1990
Stéphane Méresse, Thomas Ludwig, Rainer Frank, Bernard Hoflack   +3 more
openalex   +1 more source