Results 171 to 180 of about 17,019 (205)

Cation‐independent mannose 6‐phosphate receptor contains covalently bound fatty acid

Journal of Cellular Biochemistry, 1988
AbstractThe cation‐independent mannose 6‐phosphate receptor (215,000 daltons) was isolated from embryonic bovine tracheal cells and embryonic human skin fibroblasts labelled with [3H]palmitic acid, the tritium label was detected in the protein upon fluorographic analysis of SDS‐polyacrylamide gels of the purified receptor.
K R, Westcott, L H, Rome
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Domain 5 of the Cation-Independent Mannose 6-Phosphate Receptor Preferentially Binds Phosphodiesters (Mannose 6-Phosphate N-Acetylglucosamine Ester)

Biochemistry, 2007
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46 kDa cation-dependent MPR (CD-MPR) are key components of the lysosomal enzyme targeting system that bind newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and divert them from the secretory pathway.
Carrie A, Chavez, Richard N, Bohnsack, Mariko, Kudo, Russell R, Gotschall, William M, Canfield, Nancy M, Dahms   +5 more
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Enhancing the efficacy of cation-independent mannose 6-phosphate receptor inhibitors by intracellular delivery

Chemical Communications, 2016
Intracellular delivery of M6P/IGFII receptor inhibitors exhibits better efficacy than extracellular inhibitors to regulate TGFβ1mediated upregulation of profibrotic marker, collagen I.
Vipul, Agarwal, Priyanka, Toshniwal, Natalie E, Smith, Nicole M, Smith, Binbin, Li, Tristan D, Clemons, Lindsay T, Byrne, Foteini, Kakulas, Fiona M, Wood, Mark, Fear, Ben, Corry, K, Swaminathan Iyer   +11 more
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Cation-independent mannose 6-phosphate receptor: From roles and functions to targeted therapies

Journal of Controlled Release
The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments. Recently, the small membrane-bound portion of this receptor has appeared to be implicated in numerous pathophysiological processes.
Corentin, Gauthier, Khaled, El Cheikh, Ilaria, Basile, Morgane, Daurat, Elodie, Morère, Marcel, Garcia, Marie, Maynadier, Alain, Morère, Magali, Gary-Bobo   +8 more
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Characterization of the cation-independent mannose 6-phosphate receptor-enriched prelysosomal compartment in NRK cells

Journal of Cell Science, 1990
ABSTRACT The structure of a late endosomal compartment, which contains the bulk of the cation-independent mannose 6-phosphate receptor (MPR) in NRK cells, is documented using immunocytochemistry and cryo-sections, as well as conventional Epon sections.
G, Griffiths, R, Matteoni, R, Back, B, Hoflack   +3 more
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Retinoic Acid Induces Autophagosome Maturation Through Redistribution of the Cation-Independent Mannose-6-Phosphate Receptor

Antioxidants & Redox Signaling, 2011
Retinoic acids (RAs) have diverse biologic effects and regulate several cellular functions. Here, we investigated the role of RA on autophagy by studying its effects on autophagosome (AUT) maturation, as well as on upstream regulators of autophagosome biogenesis. Our studies, based on the use of pH-sensitive fluorescent reporter markers, suggested that
Yogendra, Rajawat, Zoe, Hilioti, Ioannis, Bossis   +2 more
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Cation-independent mannose 6- phosphate/insulin-like growth factor-· II receptor

1994
Abstract No human disease has been shown to result from deficiency of the CI-M6P/IGF-II receptor. The CI-M6P/IGF-II receptor gene is imprinted in the mouse embryo being expressed only from the maternal chromosome 17. Embryos that inherit a deletion of the T-associated maternal effect (Tme) locus from their mother die at day 15 of ...
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The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor

Experimental Cell Research, 2006
Although the role of the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CIMPR) has been well established in the receptor trafficking, that of the luminal domain is still controversial. We noticed that the peripheral distribution of GFP, fused to the transmembrane and cytoplasmic domains of CIMPR (G-CIMPR-tail), was distinct ...
Satoshi, Waguri, Yuji, Tomiyama, Hiroko, Ikeda, Tatsuhiro, Hida, Norio, Sakai, Masako, Taniike, Shigeyuki, Ebisu, Yasuo, Uchiyama   +7 more
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The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor

Experimental Cell Research, 2014
The ubiquitin proteasome system is central to the regulation of a number of intracellular sorting pathways in mammalian cells including quality control at the endoplasmic reticulum and the internalization and endosomal sorting of cell surface receptors.
Christopher J, Smith, C Jane, McGlade
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Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in HeLa cells

Cell and Tissue Research, 2004
It has been shown that the treatment with 3beta-[2-(diethylamino)ethoxy] androst-5-en-17-one (U18666A) causes the accumulation of cholesterol and the cation-independent mannose 6-phosphate receptor (CIMPR) in late endosomal/lysosomal compartments in BHK cells.
Yuji, Tomiyama, Satoshi, Waguri, Shiro, Kanamori, Satoshi, Kametaka, Masaki, Wakasugi, Masahiro, Shibata, Shigeyuki, Ebisu, Yasuo, Uchiyama   +7 more
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