Results 11 to 20 of about 17,019 (205)

Cation-Independent Mannose 6-Phosphate Receptor Deficiency Enhances β-Cell Susceptibility to Palmitate. [PDF]

Mol Cell Biol, 2018
Palmitate attenuates insulin secretion and reduces the viability of insulin-producing cells. Previous studies identified the aberrant palmitoylation or mispalmitoylation of proteins as one mechanism by which palmitate causes β-cell damage. In this report, we identify a role for lysosomal protein degradation as a mechanism by which β cells defend ...
Baldwin AC, Naatz A, Bohnsack RN, Bartosiak JT, Oleson BJ, Hansen PA, Dahms NM, Corbett JA.   +7 more
europepmc   +5 more sources

Cation-independent mannose 6-phosphate receptor: a composite of distinct phosphomannosyl binding sites. [PDF]

J Biol Chem, 2009
The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR), which contains multiple mannose 6-phosphate (Man-6-P) binding sites that map to domains 3, 5, and 9 within its 15-domain extracytoplasmic region, functions as an efficient carrier of Man-6-P-containing lysosomal enzymes.
Bohnsack RN, Song X, Olson LJ, Kudo M, Gotschall RR, Canfield WM, Cummings RD, Smith DF, Dahms NM.   +8 more
europepmc   +5 more sources

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells. [PDF]

J Cereb Blood Flow Metab, 2017
Brain capillary endothelium mediates the exchange of nutrients between blood and brain parenchyma. This barrier function of the brain capillaries also limits passage of pharmaceuticals from blood to brain, which hinders treatment of several neurological disorders.
Siupka P, Hersom MN, Lykke-Hartmann K, Johnsen KB, Thomsen LB, Andresen TL, Moos T, Abbott NJ, Brodin B, Nielsen MS.   +9 more
europepmc   +7 more sources

Residues essential for plasminogen binding by the cation-independent mannose 6-phosphate receptor. [PDF]

Biochemistry, 2010
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) is a multifunctional protein that binds diverse intracellular and extracellular ligands with high affinity. The CI-MPR is a receptor for plasminogen, and this interaction can be inhibited by lysine analogues.
Bohnsack RN, Patel M, Olson LJ, Twining SS, Dahms NM.   +4 more
europepmc   +6 more sources

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport. [PDF]

Mol Biol Cell, 2008
DOCK180 is the archetype of the DOCK180-family guanine nucleotide exchange factor for small GTPases Rac1 and Cdc42. DOCK180-family proteins share two conserved domains, called DOCK homology region (DHR)-1 and -2. Although the function of DHR2 is to activate Rac1, DHR1 is required for binding to phosphoinositides.
Hara S, Kiyokawa E, Iemura S, Natsume T, Wassmer T, Cullen PJ, Hiai H, Matsuda M.   +7 more
europepmc   +6 more sources

ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. [PDF]

Curr Biol, 2013
ArfGAPs are known to be involved in cargo sorting in COPI transport. However, the role of ArfGAPs in post-Golgi membrane traffic has not been defined. To determine the function of ArfGAPs in post-Golgi traffic, we used small interfering RNA to examine each of 25 ArfGAPs for effects on cation-independent mannose 6-phosphate receptor (CIMPR) localization.
Shiba Y, Kametaka S, Waguri S, Presley JF, Randazzo PA.   +4 more
europepmc   +5 more sources

TGN exit of the cation-independent mannose 6-phosphate receptor does not require acid hydrolase binding. [PDF]

Cell Logist, 2014
The cation-independent mannose 6-phosphate (Man-6-P) receptor (CI-MPR) binds newly synthesized, Man-6-P-containing lysosomal acid hydrolases in the trans-Golgi network (TGN) for clathrin-mediated transport to endosomes. It has remained unresolved, however, whether acid hydrolase binding is required for exit of the CI-MPR from the TGN.
van Meel E, Klumperman J.
europepmc   +5 more sources

Most rotavirus strains require the cation-independent mannose-6-phosphate receptor, sortilin-1, and cathepsins to enter cells. [PDF]

Virus Res, 2018
Díaz-Salinas MA, Casorla LA, López T, López S, Arias CF.   +4 more
europepmc   +3 more sources

Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain. [PDF]

Glycoconj J
Tang YH, Liu YS, Fujita M.
europepmc   +3 more sources

Identification of a fourth mannose 6-phosphate binding site in the cation-independent mannose 6-phosphate receptor. [PDF]

Glycobiology, 2015
The 300 kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays an essential role in lysosome biogenesis by targeting ∼ 60 different phosphomannosyl-containing acid hydrolases to the lysosome. This type I membrane glycoprotein has a large extracellular region comprised of 15 homologous domains.
Olson LJ, Castonguay AC, Lasanajak Y, Peterson FC, Cummings RD, Smith DF, Dahms NM.   +6 more
europepmc   +4 more sources