General Linker Diversification Approach to Bivalent Ligand Assembly: Generation of an Array of Ligands for the Cation-Independent Mannose 6-Phosphate Receptor. [PDF]
Org Lett, 2017 Fei X +5 more
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Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor. [PDF]
Proceedings of the National Academy of Sciences, 1987 Four overlapping cDNA clones encoding a partial sequence of the cation-independent 215-kDa mannose 6-phosphate receptor have been identified by screening a fetal calf liver cDNA library with oligonucleotide probes. RNA hybridization analysis showed that the length of the mRNA is approximately 9.5 kilobases.
Peter Lobel +4 more
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Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor.
Journal of Biological Chemistry, 1988 We have isolated and sequenced cDNA clones encoding the entire sequence of the bovine cation-independent mannose 6-phosphate receptor. The deduced 2499-amino acid precursor has a calculated molecular mass of 275 kDa. Analysis of the sequence indicates that the protein has a 44-residue amino-terminal signal sequence, a 2269-residue extracytoplasmic ...
Peter Lobel +2 more
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The N-terminal Carbohydrate Recognition Site of the Cation-independent Mannose 6-Phosphate Receptor [PDF]
Journal of Biological Chemistry, 2004 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) plays a critical role in the trafficking of newly synthesized mannose 6-phosphate-containing acid hydrolases to the lysosome. The receptor contains two high affinity carbohydrate recognition sites within its 15-domain extracytoplasmic region, with essential residues for carbohydrate ...
Linda J. Olson +2 more
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Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7–11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9 [PDF]
Structure, 2020 The cation-independent mannose 6-phosphate (M6P)/Insulin-like growth factor-2 receptor (CI-MPR/IGF2R) is an ∼300 kDa transmembrane protein responsible for trafficking M6P-tagged lysosomal hydrolases and internalizing IGF2. The extracellular region of the CI-MPR has 15 homologous domains, including M6P-binding domains (D) 3, 5, 9, and 15 and IGF2 ...
Alice Bochel +10 more
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Structural basis for recognition of phosphodiester-containing lysosomal enzymes by the cation-independent mannose 6-phosphate receptor. [PDF]
Proc Natl Acad Sci U S A, 2010 Olson LJ +8 more
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Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases. [PDF]
Mol Neurobiol, 2017 The insulin-like growth factor II/mannose 6-phosphate (IGF-II/M6P) receptor is a multifunctional single transmembrane glycoprotein. Recent studies have advanced our understanding of the structure, ligand-binding properties, and trafficking of the IGF-II/M6P receptor.
Wang Y +3 more
europepmc +4 more sources
Correction: Production of Domain 9 from the cation-independent mannose-6-phosphate receptor fused with an Fc domain. [PDF]
Glycoconj JTang YH, Liu YS, Fujita M.
europepmc +3 more sources
The glycan-binding properties of the cation-independent mannose 6-phosphate receptor are evolutionary conserved in vertebrates. [PDF]
Glycobiology, 2012 Castonguay AC +6 more
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Mouse mutants lacking the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor are impaired in lysosomal enzyme transport: comparison of cation-independent and cation-dependent mannose 6-phosphate receptor-deficient mice [PDF]
Biochemical Journal, 1998 Two proteins have been implicated in the mannose 6-phosphate-dependent transport of lysosomal enzymes to lysosomes: the 300 kDa cation-independent and the 46 kDa cation-dependent mannose 6-phosphate receptors (CI- and CD-MPRs). The mammalian CI-MPR also mediates endocytosis and clearance of insulin-like growth factor II (IGF-II).
István Sohár +4 more
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