A prodrug targeting CIM6P/IGF2R enhances memory in healthy mice and reverses deficits in an Angelman syndrome mouse model. [PDF]
Transl PsychiatryDevastating diseases of the central nervous system (CNS), such as neurodevelopmental disorders and neurodegenerative diseases, carry severe neurological symptoms, including cognitive impairment –a decline characterized by learning and memory problems ...
Aria F +8 more
europepmc +2 more sources
Ligand interactions of the cation-independent mannose 6-phosphate receptor
Journal of Biological Chemistry, 1989 The interactions of the bovine cation-dependent mannose 6-phosphate receptor with monovalent and divalent ligands have been studied by equilibrium dialysis. This receptor appears to be a homodimer or a tetramer. Each mole of receptor monomer bound 1.2 mol of the monovalent ligands, mannose 6-phosphate and pentamannose phosphate with Kd values of 8 X 10(
P Y Tong, W Gregory, S Kornfeld
openaire +4 more sources
The cation‐independent mannose‐6‐phosphate receptor binds to soluble GPI‐linked proteins via mannose‐6‐phosphate [PDF]
FEBS Letters, 1995 The cation‐independent mannose‐6‐phosphate/insulin‐like growth factor II receptor has been observed to bind to soluble forms of glycosyl‐phosphatidylinositol‐linked molecules, one of mammalian origin (rat Thy‐1) and two of protozoan origins. Of the two phosphate groups found on the soluble forms of the protozoan glycosyl‐phosphatidylinositol‐linked ...
Green, Paula J. +3 more
openaire +4 more sources
Cation-dependent mannose-6-phosphate receptor expression and distribution are influenced by estradiol in MCF-7 breast cancer cells. [PDF]
PLoS ONE, 2018 Cancer cells secrete procathepsin D, and its secretion is enhanced by estradiol. Although alterations in the pro-enzyme intracellular transport have been reported, the mechanism by which it is secreted remains poorly understood.
N Bannoud +5 more
doaj +1 more source
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease [PDF]
, 2016 Increasing evidence points to defects in autophagy as a common denominator in most neurodegenerative conditions. Progressive functional decline in the autophagy-lysosomal pathway (ALP) occurs with age, and the consequent impairment in protein processing ...
Andresen, Thomas Lars +10 more
core +17 more sources
The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide. [PDF]
Biochem J, 2006 Damen E +4 more
europepmc +3 more sources
A role for CIM6P/IGF2 receptor in memory consolidation and enhancement
eLife, 2020 Cation-independent mannose-6-phosphate receptor, also called insulin-like growth factor two receptor (CIM6P/IGF2R), plays important roles in growth and development, but is also extensively expressed in the mature nervous system, particularly in the ...
Xiao-Wen Yu +3 more
doaj +1 more source
Linagliptin Limits High Glucose Induced Conversion of Latent to Active TGFß through Interaction with CIM6PR and Limits Renal Tubulointerstitial Fibronectin. [PDF]
PLoS ONE, 2015 In addition to lowering blood glucose in patients with type 2 diabetes mellitus, dipeptidyl peptidase 4 (DPP4) inhibitors have been shown to be antifibrotic.
Muralikrishna Gangadharan Komala +4 more
doaj +1 more source
Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting [PDF]
Bioorganic & Medicinal Chemistry Letters, 2008 The cation-independent mannose 6-phosphate receptor (CI-M6PR) is essential for the endocytosis of proteins bearing the mannose 6-phosphate (M6P) recognition marker. This study described the synthesis of M6P and M6S analogs presenting greater affinity for CI-M6PR than their natural compounds. Moreover, the finding of their lack of cytotoxicity for human
Audrey Jeanjean +5 more
openalex +5 more sources
Identification of a Low Affinity Mannose 6-Phosphate-binding Site in Domain 5 of the Cation-independent Mannose 6-Phosphate Receptor [PDF]
Journal of Biological Chemistry, 2004 The 300-kDa cation-independent mannose 6-phosphate receptor (CI-MPR) and the 46-kDa cation-dependent MPR (CD-MPR) are type I integral membrane glycoproteins that play a critical role in the intracellular delivery of newly synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases to the lysosome.
Sreelatha T. Reddy +5 more
openalex +4 more sources