Results 51 to 60 of about 17,019 (205)

The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Acta Neuropathologica Communications, 2019
The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer’s disease (AD). In
Hermeto Gerber, Sebastien Mosser, Benjamin Boury-Jamot, Michael Stumpe, Alessandra Piersigilli, Christine Goepfert, Joern Dengjel, Urs Albrecht, Fulvio Magara, Patrick C. Fraering   +9 more
doaj   +1 more source

Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice. [PDF]

PLoS ONE, 2013
Sorting nexin 5 (Snx5) has been posited to regulate the degradation of epidermal growth factor receptor and the retrograde trafficking of cation-independent mannose 6-phosphate receptor/insulin-like growth factor II receptor. Snx5 has also been suggested
Sun-Kyoung Im, HyoBin Jeong, Hyun-Woo Jeong, Kyong-Tai Kim, Daehee Hwang, Machiko Ikegami, Young-Yun Kong   +6 more
doaj   +1 more source

Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes

Frontiers in Cardiovascular Medicine, 2021
Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts.
Lin Cui, Qiong Zhang, Yao Huang, Lei Yang, Junhui Zhang, Junhui Zhang, Xupin Jiang, Xupin Jiang, Jiezhi Jia, Yanling Lv, Dongxia Zhang, Yuesheng Huang   +11 more
doaj   +1 more source

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells [PDF]

, 2008
Mannose 6-phosphate receptors (MPRs) are transported from endosomes to the Golgi after delivering lysosomal enzymes to the endocytic pathway. This process requires Rab9 guanosine triphosphatase (GTPase) and the putative tether GCC185.
Espinosa, Eric, Ganley, Ian G., Pfeffer, Suzanne R.   +2 more
core   +4 more sources

Parkinson disease-linked Vps35 R524W mutation impairs the endosomal association of retromer and induces α-synuclein aggregation [PDF]

, 2016
Endosomal sorting is a highly orchestrated cellular process. Retromer is a heterotrimeric complex that associates with endosomal membranes and facilitates the retrograde sorting of multiple receptors, including the cation-independent mannose 6-phosphate ...
Ariotti, Nicholas, Bugarcic, Andrea, Collins, Brett M., Follett, Jordan, Norwood, Suzanne J., Parton, Robert G., Teasdale, Rohan D., Yang, Zhe   +7 more
core   +1 more source

The cation-independent mannose 6-phosphate receptor is involved in lysosomal delivery of serglycin [PDF]

Journal of Leukocyte Biology, 2007
AbstractTo clarify the sorting mechanism of the lysosomal/granular proteoglycan serglycin, we treated human promonocytic U937 cells with p-nitrophenyl-β-D-xyloside (PNP-xyl) and cycloheximide. In the absence of protein synthesis, the carbohydrate moiety of serglycin was synthesized as PNP-xyl-chondroitin sulfate (CS), and most of it was delivered to ...
Peter, Lemansky, Ines, Fester, Eva, Smolenova, Christoph, Uhländer, Andrej, Hasilik   +4 more
openaire   +2 more sources

In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor

Blood Cells, Molecules, and Diseases, 2009
Hereditary hemochromatosis is most frequently associated with mutations in HFE, which encodes a class Ib histocompatibility protein. HFE binds to the transferrin receptor-1 (TfR1) in competition with iron-loaded transferrin (Fe-Tf). HFE is released from TfR1 by increasing concentrations of Fe-Tf, and free HFE may then regulate iron homeostasis by ...
Schimanski, L, Drakesmith, H, Sweetland, E, Bastin, J, Rezgui, D, Edelmann, M, Kessler, B, Merryweather-Clarke, A, Robson, K, Townsend, A   +9 more
openaire   +3 more sources

Insulin-like growth factors and related proteins in plasma and cerebrospinal fluids of HIV-positive individuals. [PDF]

, 2015
BackgroundClinically significant dysregulation of the insulin-like growth factor (IGF) family proteins occurs in HIV-infected individuals, but the details including whether the deficiencies in IGFs contribute to CNS dysfunction are unknown.MethodsWe ...
Choi, Namjong, Lee, Sunhee C, Letendre, Scott, Lo, Yungtai, Suh, Hyeon-Sook   +4 more
core   +2 more sources

A study on the safety and efficacy of reveglucosidase alfa in patients with late-onset Pompe disease. [PDF]

, 2017
BackgroundLate-onset Pompe disease is a rare genetic neuromuscular disorder caused by lysosomal acid alpha-glucosidase (GAA) deficiency that ultimately results in mobility loss and respiratory failure.
Barohn, Richard, Barshop, Bruce A, Bratkovic, Drago, Byrne, Barry J, Desnuelle, Claude, Geberhiwot, Tarekegn, Haroldsen, Peter, Hughes, Derralynn, Jayaram, Kala, Laforet, Pascal, Mengel, Eugen, POM-001/002 Investigators, Reilley, Kristin, Roberts, Mark, Walsh, Liron, Yang, Ke   +15 more
core   +2 more sources

IGF2-tagging of GAA promotes full correction of murine Pompe disease at a clinically relevant dosage of lentiviral gene therapy

Molecular Therapy: Methods & Clinical Development, 2022
Pompe disease is caused by deficiency of acid α-glucosidase (GAA), resulting in glycogen accumulation in various tissues, including cardiac and skeletal muscles and the central nervous system (CNS).
Qiushi Liang, Fabio Catalano, Eva C. Vlaar, Joon M. Pijnenburg, Merel Stok, Yvette van Helsdingen, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, W.W.M. Pim Pijnappel   +9 more
doaj   +1 more source